Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18tm1Akis mutation
(0 available);
any
Tbx18 mutation
(36 available)
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cardiovascular system
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• at E14.5, veins within the heart are thinner and smaller and are abnormally positioned within the membranous wall
• at the cranial level, veins are shifted laterally and are surrounded by lung tissue
• myocardial differentiation of the walls of the systemic veins is delayed
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• at E10.5, all mice fail to form a left sinus horn in the pericadial cavity
• at E10.5, sinus horn precursor cells are decreased
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• at E14.5, hearts have thinner and smaller veins that are abnormally positioned within the membranous wall
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18tm1Akis mutation
(0 available);
any
Tbx18 mutation
(36 available)
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mortality/aging
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• homozygous mice die shortly after birth from respiratory failure
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craniofacial
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• partial or complete fusion of the occipital bone and the atlas occurs in some homozygous mice
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embryo
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• marker expression patterns indicate that anterior-posterior polarity is not maintained within the lateral sclerotome
• at E10.5 cell density differences and cellular prolifration differences between the anterior and posterior lateral sclerotome are absent in homozygous mutants
• apoptosis is increased in the anterior portion of the lateral sclerotome in homozygous mutants compared to wild-type mice
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growth/size/body
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• mutant pups are born with a shortened body
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skeleton
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• the segmental organization of the attached ribs is impaired in the cervical and thoracic regions
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• fusion of the distal ribs is occasionally seen
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• intervertebral disc are reduced and delocalized
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• partial or complete fusion of the occipital bone and the atlas occurs in some homozygous mice
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• expansion of the ossification centers of vertebral bodies in the thoracic region is occasionally seen
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• the pedicles within the lumbar region are symmetrical rather than polarized in shape as in wild-type mice
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• the segmental organization of the vertebrae is impaired in the cervical and thoracic regions
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• the pedicles of the neural arches with their transverse processes and the proximal regions of the ribs are expanded to form contiguous bony bands
• at E14.5 the pedicles in the cervical and thoracic regions and proximal ribs are expanded to form contiguous bands
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nervous system
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• from E10.5 on partial fusion of the dorsal root ganglia can be seen
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• at E10.5 spinal nerve projections are partially lost or deflected from their path
• spinal nerves transversing anterior somite halves appear thinner
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18tm1Akis mutation
(0 available);
any
Tbx18 mutation
(36 available)
Tbx18tm4(cre)Akis mutation
(0 available);
any
Tbx18 mutation
(36 available)
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cardiovascular system
N |
• mice exhibit normal epicardial development at E18.5
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