Phenotypes associated with this allele

• Allele Symbol: Syce1^tm1Hgu
• Allele Name: targeted mutation 1, MRC Human Genetics Unit
• Allele ID: MGI:3840564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syce1^tm1Hgu/Syce1^tm1Hgu	involves: 129S7/SvEvBrd * C57BL/6	MGI:3840565

Genotype
MGI:3840565

hm1

• Allelic Composition: Syce1^tm1Hgu/Syce1^tm1Hgu
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Syce1^tm1Hgu/Syce1^tm1Hgu mice show severe defects in gametogenesis

reproductive system

azoospermia ( J:146770 )

♂ • testis lack post-meiotic cells unlike in wild-type mice

arrest of male meiosis ( J:146770 )

♂ • spermatocytes arrest during pachynema due to chromosome synapsis failure unlike in wild-type mice

abnormal synaptonemal complex ( J:146770 )

• spermatocytes arrest during pachynema due to chromosome synapsis failure unlike in wild-type mice

increased male germ cell apoptosis ( J:146770 )

♂ • most germ cells undergo apoptosis by stage IV

decreased mature ovarian follicle number ( J:146770 )

♀ • mice exhibit an almost complete lack of ovarian follicles

small ovary ( J:146770 )

♀ • minute in size

small testis ( J:146770 )

♂ • 20% to 30% of normal size

female infertility ( J:146770 )

♀

male infertility ( J:146770 )

♂

cellular

azoospermia ( J:146770 )

♂ • testis lack post-meiotic cells unlike in wild-type mice

arrest of male meiosis ( J:146770 )

♂ • spermatocytes arrest during pachynema due to chromosome synapsis failure unlike in wild-type mice

abnormal synaptonemal complex ( J:146770 )

• spermatocytes arrest during pachynema due to chromosome synapsis failure unlike in wild-type mice

increased male germ cell apoptosis ( J:146770 )

♂ • most germ cells undergo apoptosis by stage IV

abnormal double-strand DNA break repair ( J:146770 )

• double-strand breaks that form during meiosis fail to be efficiently repaired unlike in wild-type cells

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:146770 )

• double-strand breaks that form during meiosis fail to be efficiently repaired unlike in wild-type cells

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:146770 )

♀ • mice exhibit an almost complete lack of ovarian follicles

small ovary ( J:146770 )

♀ • minute in size

small testis ( J:146770 )

♂ • 20% to 30% of normal size