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Phenotype Image Detail
Image
Caption Hematoxylin and eosin (H&E) stained adult ovaries (A) and testes (B) from wild-type (Syce1+/+) and Syce1tm1Hgu/Syce1tm1Hgu (Syce1-/-) mice. A: Mutant ovaries are greatly reduced in size and almost completely depleted of follicles in comparison to wild-type littermate with numerous follicles. B: All stages of the spematogenic cycle are apparent in the wild-type testis. Mutant testis shows a reduced diameter of the seminferous tubules and lack of postmeiotic stages. Insets, TUNEL assay for apoptotic cells. Occasional positive cells are present in the wild-type testis. In contrast, tubules with large number of positive cells were found in the mutant testis.
Copyright This image is from Bolcun-Filas E, PLoS Genet 2009 Feb;5(2):e1000393, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:146770
Associated
Alleles
Symbol Name
Syce1tm1Hgu synaptonemal complex central element protein 1; targeted mutation 1, MRC Human Genetics Unit
Associated
Genotypes
Allelic Composition Genetic Background
Syce1tm1Hgu/Syce1tm1Hgu involves: 129S7/SvEvBrd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory