Syce1^tm1Hgu
Targeted Allele Detail

Summary

• Symbol: Syce1^tm1Hgu
• Name: synaptonemal complex central element protein 1; targeted mutation 1, MRC Human Genetics Unit
• MGI ID: MGI:3840564
• Gene: Syce1 Location: Chr7:140357142-140367765 bp, - strand Genetic Position: Chr7, 85.96 cM, cytoband F5
• Alliance: Syce1^tm1Hgu page

Syce1^tm1Hgu/Syce1^tm1Hgu mice show severe defects in gametogenesis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146770
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 through 11 were replaced with an IRES/lacZ and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on testis extracts. (J:146770)

Generation of the Syce1^tm1Hgu allele

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Syce1 Mutation: 30 strains or lines available

References

• Original: J:146770 Bolcun-Filas E, et al., Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. PLoS Genet. 2009 Feb;5(2):e1000393
• All: 3 reference(s)