All Phenotypes Hes1<tm1Kag> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hes1^tm1Kag
targeted mutation 1, Ryoichiro Kageyama
MGI:3808031

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Kag/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808127
cn2	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808125
cn3	Hes1^tm1Kag/Hes1^tm1Kag Foxa2^{tm3.1(icre)Heli}/Foxa2⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5428766
cn4	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3808124
cn5	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Hes1^tm1Kag/Hes1^tm1Kag	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5506744

Allelic Composition	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Kag/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (21 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
Tg(Nes-cre/ERT2)5-1Kag mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139170 )

N	• mice exhibit no change in Cajal-Retzius cell number

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (21 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

abnormal brain morphology ( J:139170 )

• mice exhibit mild abnormalities in the cortical hem and cortical neuroepithelium

increased Cajal-Retzius cell number ( J:139170 )

• at E11.5 and E12.5, the number of Cajal-Retzius cells in the marginal zone of the piriform cortex is increased compared to in wild-type mice

absent choroid plexus ( J:139170 )

embryo

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

cellular

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

Allelic Composition	Hes1^tm1Kag/Hes1^tm1Kag Foxa2^{tm3.1(icre)Heli}/Foxa2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2^{tm3.1(icre)Heli} mutation (0 available); any Foxa2 mutation (26 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas development ( J:184814 )

• embryos show an increase in Neurog3+ve cells at E9.5; by E10.5, an increase in glucagon+ve cells is seen

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos similar to the dnMaml-expressing embryos

• some DBA+ve cells are observed in E18.5 embryos

• proximal-distal patterning is altered in the embryonic pancreas; at E15.5, Nkx6-1+ve, Ptf1a-ve cells are reduced in the proximal domain by 85% while Hnf1b and DBA+ve cells are reduced in number with a concurrent increase in Nkx6-1-ve, Ptf1a+ve cells as well as Cpa+ve and amylase +ve cells

• Nkx6-1 and Ptf1a double-positive cells are observed in significant numbers

• at E12.5, Nkx6-1+ve Ptf1a-ve are present, but reduced in numbers by 50% compared to controls along with no increase in Nkx6-1-ve Ptf1a+ve cells

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

cellular

abnormal pancreatic beta cell differentiation ( J:184814 )

• at E15.5, the insulin +ve area of the pancreatic tissue is reduced by 65% compared to control embryos

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139170 )

N	• mice exhibit normal telencephalon development

Allelic Composition	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Hes1^tm1Kag/Hes1^tm1Kag
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alb^{tm1(cre/ERT2)Mtz} mutation (1 available); any Alb mutation (91 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:192740 )

N	• after 14 weeks of tamoxifen administration, neoplastic nodules are not found in livers of mice; intrahepatic cholangiocarcinoma (ICC) does not develop in absence of Notch1- mediated conversion of hepatocytes into biliary lineage cells

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