Foxa2^{tm3.1(icre)Heli}
Targeted Allele Detail

Summary

• Symbol: Foxa2^{tm3.1(icre)Heli}
• Name: forkhead box A2; targeted mutation 3.1, Heiko Lickert
• MGI ID: MGI:5426440
• Synonyms: Foxa2^T2AiCre, Foxa2^{tm1.1(icre)Hri}
• Gene: Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
• Alliance: Foxa2^{tm3.1(icre)Heli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184814
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Foxa2^{tm3.1(icre)Heli} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxa2 (MGI:1347476)

• Mutation details: A targeting construct introduced a T2A sequence and a codon improved cre (icre) sequence with an Frt-flanked neo cassette into exon 3 of the Foxa2 locus. The neo was removed from the germline by Flp-e mediated excision. (J:184814)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa2 (mouse) Summary of all recombinase alleles driven by Foxa2. Comparative matrix view of recombinase activities Alliance mouse Foxa2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa2 Mutation: 26 strains or lines available

References

• Original: J:184814 Horn S, et al., Mind bomb 1 is required for pancreatic beta-cell formation. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
• All: 8 reference(s)