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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sox1tm1(cre)Take
targeted mutation 1, Takumi Era
MGI:3807952
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dicer1tm1Bdh/Dicer1tm1Bdh
Sox1tm1(cre)Take/Sox1+
involves: 129 * C57BL/6NCrlj * CBA/JNCrlj MGI:6156401
cn2
Eomestm1Rob/Eomestm1Rob
Sox1tm1(cre)Take/0
involves: 129S/SvEv * C57BL/6 * CBA MGI:3808022
cn3
Fkrptm1Scbr/Fkrptm1Scbr
Sox1tm1(cre)Take/Sox1+
Tg(CAG-LARGE)126Fmu/0
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj MGI:5556065
cn4
Fkrptm1Scbr/Fkrptm1Scbr
Sox1tm1(cre)Take/Sox1+
involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5556062
cn5
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Sox1tm1(cre)Take/Sox1+
involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5527437


Genotype
MGI:6156401
cn1
Allelic
Composition
Dicer1tm1Bdh/Dicer1tm1Bdh
Sox1tm1(cre)Take/Sox1+
Genetic
Background
involves: 129 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (4 available); any Dicer1 mutation (92 available)
Sox1tm1(cre)Take mutation (1 available); any Sox1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo




Genotype
MGI:3808022
cn2
Allelic
Composition
Eomestm1Rob/Eomestm1Rob
Sox1tm1(cre)Take/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1Rob mutation (0 available); any Eomes mutation (41 available)
Sox1tm1(cre)Take mutation (1 available); any Sox1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increased exploratory behavior in the open field test
• enhanced aggressiveness upon handling
• male mutants mutilated or killed pups
• significantly reduced grip strength

nervous system
• enhanced cell death in the dentate migration stream
• fraction of callosal axons are misrouted
• the typical input-related patterning in Barrel cortex was strongly diminished
• significant decrease of nonventricular surface proliferation during cortical development
• expression of subventricular zone (SVZ) markers were reduced indicating about 25% decrease of proliferating cells in the mutant SVZ throughout development
• neurogenesis in the dentate gyrus was completely absent
• nerurogenesis in th subependymal zone of adult mutants appeared normal
• despite normal body weight, mutant brains showed a markedly reduced brain size
• the size of the cortex and the olfactory bulbs was markedly reduced at birth
• the contralateral projecting fibers from olfactory nuclei and temporal lobes which forms the anterior commissure were absent
• the infrapyramidal blade did not develop
• cortical layers II-IV thickness is reduced
• the mitral cell layer in the olfactory bulb is absent

cellular
• enhanced cell death in the dentate migration stream
• fraction of callosal axons are misrouted
• the typical input-related patterning in Barrel cortex was strongly diminished
• significant decrease of nonventricular surface proliferation during cortical development
• expression of subventricular zone (SVZ) markers were reduced indicating about 25% decrease of proliferating cells in the mutant SVZ throughout development
• neurogenesis in the dentate gyrus was completely absent
• nerurogenesis in th subependymal zone of adult mutants appeared normal




Genotype
MGI:5556065
cn3
Allelic
Composition
Fkrptm1Scbr/Fkrptm1Scbr
Sox1tm1(cre)Take/Sox1+
Tg(CAG-LARGE)126Fmu/0
Genetic
Background
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkrptm1Scbr mutation (2 available); any Fkrp mutation (21 available)
Sox1tm1(cre)Take mutation (1 available); any Sox1 mutation (13 available)
Tg(CAG-LARGE)126Fmu mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• poor health results in sacrifice at around 27 weeks of age

muscle
• individual muscle fibers are occasionally surrounded by moderate to large amounts of compact, fibrous connective tissue and infiltrates of fat with some muscle fibers mineralized
• mice surviving to 30 weeks exhibit hypertrophy of muscle fibers
• presence of large calcium deposits in muscle
• mice display more severe muscle phenotype than Fkrptm1Scbr Sox1tm1(cre)Take mice
• variation in fiber size, centrally nucleated muscle fibers and increases in the number of split fibers at 12 weeks of age
• pronounced expansion of the interstitium with small to moderate amounts of variably mature fibroadipose tissue and substantial inflammation in the interstitium and necrotic muscle fibers comprised of neutrophils, macrophages, and lesser numbers of lymphocytes and plasma cells
• muscle shows a reduction in resistance to eccentric contraction-induced injury (isometric force in the last contraction) relative to controls
• substantial inflammation in the interstitium and necrotic muscle fibers comprised of neutrophils, macrophages, and lesser numbers of lymphocytes and plasma cells

behavior/neurological
• partial collapse of the leg extensor reflex

immune system
• substantial inflammation in the interstitium and necrotic muscle fibers comprised of neutrophils, macrophages, and lesser numbers of lymphocytes and plasma cells




Genotype
MGI:5556062
cn4
Allelic
Composition
Fkrptm1Scbr/Fkrptm1Scbr
Sox1tm1(cre)Take/Sox1+
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkrptm1Scbr mutation (2 available); any Fkrp mutation (21 available)
Sox1tm1(cre)Take mutation (1 available); any Sox1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected numbers are seen when double heterozygotes are mated to single heterozygous Fkrp mutant mice
• high pre-weaning loss is seen when double heterozygotes are mated together

growth/size/body
• females, but not males, show a reduced body weight at 20 but not at 12 weeks of age

muscle
• macrophages, lymphocytes, and rare plasma cells infiltrate the interstitium and necrotic myofibers
• mice develop a progressive muscular dystrophy
• by 6 weeks of age, occasional areas of small basophilic regenerating fibers and inflammatory infiltrates are see in gastrocnemius muscle
• by 12 weeks of age, the gastrocnemius and diaphragm show fiber degeneration characterized by sarcoplasmic hyalinization, loss of cross striations and sarcoplasmic fragmentation and groups of small, regenerative myofibers with large, centralized nuclei and a granular pale basophilic cytoplasm
• at 30 weeks, muscle fiber degeneration is attenuated and regeneration with clusters of basophilic regenerative fibers is occasionally evident together with rare, interstitial lymphoplasmacytic foci
• however, the soleus muscle shows only minimal damage even at 30 weeks of age
• gastrocnemius and diaphragm muscles show onset of fiber degeneration at around 6 weeks of age

immune system
• macrophages, lymphocytes, and rare plasma cells infiltrate the interstitium and necrotic myofibers

nervous system
• when double heterozygotes are mated together, some homozygous Fkrp offspring exhibit hydrocephalus




Genotype
MGI:5527437
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Sox1tm1(cre)Take/Sox1+
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata mutation (0 available); any Gt(ROSA)26Sor mutation (956 available)
Sox1tm1(cre)Take mutation (1 available); any Sox1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are obtained in normal Mendelian ratios

cardiovascular system
N
• at E10.5, mice exhibit no enhancement of endothelial cells

hematopoietic system
N
• at E10.5, mice exhibit no enhancement of hematopoietic progenitor cells

embryo
N
• mice develop without phenotypic abnormalities during embryogenesis





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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory