Analysis Tools
mortality/aging
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• all embryos are lost before E9.5
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Allele Symbol Allele Name Allele ID |
Hdac3tm1.1Swh targeted mutation 1.1, Scott W Heibert MGI:3793479 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all embryos are lost before E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• several markers of DNA damage are increased in MEFs at 72 h after adenoviral cre infection
• blocking progression through the cell cycle by serum starving cells reduces the amount of DNA damage detected
• sensitivity to DNA damage by ionizing radiation is also increased in adenoviral cre infected MEFs
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• impaired cell cycle progression prior to metaphase in adenoviral cre infected MEFs
• viral cre infected cells display about a 2 h delay in moving from S phase through G2/M and re-entering G1
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• by 120 h post adenoviral cre infection about 20 - 30% of MEFs are dying
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• about a 2-fold reduction in BrdU positive MEFs after adenoviral cre infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2 weeks after the final pIpC injection liver size is increased about 2-fold
• gradual increase in hypertrophic hepatocytes with grainy cytoplasm following pIpC injections
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• 2 weeks after the final pIpC injection liver weight is increased about 2-fold
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• dramatic depletion of glycogen in hepatocytes after pIpC injections
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• gradual increase in hypertrophic hepatocytes with grainy cytoplasm following pIpC injections
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• after pIpC injections
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• dramatic depletion of glycogen in hepatocytes after pIpC injections
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• 2 weeks after the final pIpC injection liver size is increased about 2-fold
• gradual increase in hypertrophic hepatocytes with grainy cytoplasm following pIpC injections
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• 2 weeks after the final pIpC injection liver weight is increased about 2-fold
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired cell cycle progression prior to metaphase in tamoxifen treated MEFs
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• in MEFs following tamoxifen treatment
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• several markers of DNA damage are increased in MEFs after tamoxifen treatment
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• several markers of DNA damage are increased in MEFs after tamoxifen treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike homozygous null mice, mice with loss of expression in the liver after birth are viable
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• at 6 - 8 weeks of age, but not at P17, the number of proliferating cells is increased
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• by P28 livers are hypertrophic
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• ratio of liver weight to body weight is increased to about 25 - 30% compared to about 5% in heterozygous mice
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• dramatic depletion of glycogen in hepatocytes
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• up to a 17-fold increase in triglyceride levels in the liver at P17
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• cells with abnormal cytoplasm are apparent at P17
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• accumulation of lipid droplets
• elevated triglyceride levels at P17
• treating mice with rapamycin reduces neutral lipid accumulation but does not alter the increase in liver size
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• by P28
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• increases with age
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• by P17
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• present by 6 weeks of age but not at P17
• at 10 weeks of age fasting glucose level is almost 2-fold lower than in control littermates
• however, glucose tolerance is not significantly different from controls
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• slightly lower at P17
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• dramatic decrease by P28 which persists as mice age
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• dramatic depletion of glycogen in hepatocytes
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• increases with age
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• increases with age
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• increases with age
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• up to a 17-fold increase in triglyceride levels in the liver at P17
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• by 4 - 6 weeks of age
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• by P28 livers are hypertrophic
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• ratio of liver weight to body weight is increased to about 25 - 30% compared to about 5% in heterozygous mice
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• visibly leaner with a substantial reduction in visceral adipose tissue by 6 - 8 weeks of age
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• at 6 - 8 weeks of age, but not at P17, the number of proliferating cells is increased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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