Hdac3^tm1Swh
Targeted Allele Detail

Summary

• Symbol: Hdac3^tm1Swh
• Name: histone deacetylase 3; targeted mutation 1, Scott W Heibert
• MGI ID: MGI:3793477
• Synonyms: Hdac3^FL
• Gene: Hdac3 Location: Chr18:38070024-38088073 bp, - strand Genetic Position: Chr18, 19.81 cM, cytoband B3
• Alliance: Hdac3^tm1Swh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134665
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of exon 7 and an additional loxP site was inserted upstream of exon 7. (J:134665)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac3 Mutation: 31 strains or lines available

References

• Original: J:134665 Bhaskara S, et al., Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell. 2008 Apr 11;30(1):61-72
• All: 31 reference(s)