Hdac3^tm1.1Swh
Targeted Allele Detail

Summary

• Symbol: Hdac3^tm1.1Swh
• Name: histone deacetylase 3; targeted mutation 1.1, Scott W Heibert
• MGI ID: MGI:3793479
• Gene: Hdac3 Location: Chr18:38070024-38088073 bp, - strand Genetic Position: Chr18, 19.81 cM, cytoband B3
• Alliance: Hdac3^tm1.1Swh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134665
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recobination was used to remove exon 7. The absence of protein product from this allele was confirmed by western blot analysis on extracts from mouse embryonic fibroblasts in which the allele has been recreated by cre-mediated recombination. (J:134665)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac3 Mutation: 31 strains or lines available

References

• Original: J:134665 Bhaskara S, et al., Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell. 2008 Apr 11;30(1):61-72
• All: 5 reference(s)