Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.1Gxu mutation
(0 available);
any
Tet1 mutation
(142 available)
Tet1tm1Gxu mutation
(0 available);
any
Tet1 mutation
(142 available)
Tg(Nes-cre/ERT2)KEisc mutation
(1 available)
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nervous system
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• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
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• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice
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cellular
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• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
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• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice
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nervous system
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• 20 days after tamoxifen treatment, mice exhibit a transient increase in hippocampal neurogenesis compared with control mice
• tamoxifen-treatment increased hippocampal neurogenesis in vitro and in vivo compared with controls
• tamoxifen-treated mice exhibit premature exit of quiescence compared with control mice
• tamoxifen-treated mice exhibit loss of neurogenic capacity of adult neurospheres and decreased neurogenesis over time compared with control mice
• neurospheres treated from tamoxifen-treated mice exhibit reduced self-renewal capacity compared with wild-type cells
• however, hippocampal neurogenesis is normal 10 and 30 days after tamoxifen treatment
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• in tamoxifen-treated mice
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• tamoxifen-treated mice exhibit decreased adult-generated immature and mature granule neurons compared with control mice
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cellular
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• 20 days after tamoxifen treatment, mice exhibit a transient increase in hippocampal neurogenesis compared with control mice
• tamoxifen-treatment increased hippocampal neurogenesis in vitro and in vivo compared with controls
• tamoxifen-treated mice exhibit premature exit of quiescence compared with control mice
• tamoxifen-treated mice exhibit loss of neurogenic capacity of adult neurospheres and decreased neurogenesis over time compared with control mice
• neurospheres treated from tamoxifen-treated mice exhibit reduced self-renewal capacity compared with wild-type cells
• however, hippocampal neurogenesis is normal 10 and 30 days after tamoxifen treatment
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• in tamoxifen-treated mice
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Analysis Tools