Tg(Nes-cre/ERT2)KEisc
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/ERT2)KEisc
• Name: transgene insertion K, Amelia Eisch
• MGI ID: MGI:3767432
• Synonyms: Nestin-CreER^T2, Tg(Nes-cre/ERT2)KJejo, Tg(Nes-cre/ESR1)KJejo, Tg(Nes-cre)KJejo
• Transgene: Tg(Nes-cre/ERT2)KEisc Location: unknown
• Alliance: Tg(Nes-cre/ERT2)KEisc page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/ERT2)KEisc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: The Nestin-cre/ERT2 transgene was designed with the rat nestin (Nes) promoter driving expression of a CreERT2 fusion gene (cre/ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand-binding domain). The transgene was microinjected into fertilized C57BL/6J oocytes, and line K was established. (J:117032, J:141562)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:117032 Battiste J, et al., Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 2007 Jan;134(2):285-93
• All: 122 reference(s)