Tet1tm1.1Gxu
Targeted Allele Detail
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Symbol: |
Tet1tm1.1Gxu |
Name: |
tet methylcytosine dioxygenase 1; targeted mutation 1.1, Guo-Liang Xu |
MGI ID: |
MGI:5523869 |
Gene: |
Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
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Alliance: |
Tet1tm1.1Gxu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:201001
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 13. Cre-mediated recombination removed exons 11 and through 13 (encoding the critical catalytic domain in dioxygenases) and the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in the cortex, hippocampus and cerebellum.
(J:201001)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tet1 Mutation: |
142 strains or lines available
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Original: |
J:201001 Zhang RR, et al., Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell. 2013 Aug 1;13(2):237-45 |
All: |
8 reference(s) |
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