Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.1Gxu mutation
(0 available);
any
Tet1 mutation
(142 available)
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behavior/neurological
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• in a 5-day acquisition trials in a Morris water maze, mice exhibit delayed learning based on escape latency and swim path compared with wild-type mice
• impaired short term memory retention 24 hours after a 5-day training in a Morris water maze
• however, long term memory after 3 weeks is normal
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• impaired short term memory retention 24 hours after a 5-day training in a Morris water maze
• however, long term memory after 3 weeks is normal
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nervous system
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• adult mice exhibit normal brain morphology
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.1Gxu mutation
(0 available);
any
Tet1 mutation
(142 available)
Tg(Nes-EGFP)33Enik mutation
(1 available)
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nervous system
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• mice exhibit reduced adult subgranular zone neural progenitor pools compared with wild-type mice
• dentate gyrus primary neurospheres exhibit reduced self-renewal compared with wild-type cells
• however, differentiation potential is normal and galanin supplementation partially rescues proliferation
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cellular
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• mice exhibit reduced adult subgranular zone neural progenitor pools compared with wild-type mice
• dentate gyrus primary neurospheres exhibit reduced self-renewal compared with wild-type cells
• however, differentiation potential is normal and galanin supplementation partially rescues proliferation
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• neuronal progenitor cells exhibit hypermethylation compared with wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.1Gxu mutation
(0 available);
any
Tet1 mutation
(142 available)
Tet1tm1Gxu mutation
(0 available);
any
Tet1 mutation
(142 available)
Tg(Nes-cre/ERT2)KEisc mutation
(1 available)
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nervous system
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• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
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• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice
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cellular
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• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
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• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice
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Analysis Tools