Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation
(0 available);
any
Klf2 mutation
(12 available)
Krit1tm1Kwhi mutation
(0 available);
any
Krit1 mutation
(34 available)
Tg(Cdh5-cre/ERT2)1Rha mutation
(3 available)
|
|
|
cardiovascular system
|
|
• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation
|
nervous system
|
|
• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation
(0 available);
any
Klf2 mutation
(12 available)
Krit1tm1Kwhi mutation
(0 available);
any
Krit1 mutation
(34 available)
Tg(Cdh5-cre/ERT2)1Rha mutation
(3 available)
|
|
|
nervous system
|
N |
• mice exhibit 99% rescue of cerebral cavernous malformation lesion formation, with only a small amount of venule dilatation visible
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation
(0 available);
any
Klf2 mutation
(12 available)
Tg(Tek-cre)12Flv mutation
(1 available)
|
|
|
mortality/aging
|
|
• embryos are all dead by E14.5
|
cardiovascular system
|
|
• by E12.5, the myocardium of is only 1-2 cell layers thick compared to a thickness of 5 cell layers or more in littermate controls
|
|
|
• by E12.5, the myocardium has pulled away from the epicardium
|
|
|
• by E12.5, large effusions are apparent around the embryonic heart
|
|
|
• in E11.5 embryos, cardiac outputs are nearly 3 fold higher than in littermate controls
|
|
|
• in E11.5 embryos, left ventricular stroke volume is 2.5 fold higher than in controls
• no evidence of valvular regurgitation is detected, indicating that excess flow is in the outward direction
|
|
|
• maternal administration of a smooth muscle tone agonist rescues half of E14.5 embryos from lethality related to cardiac failure
|
|
|
• at E12.5, 25% of embryos lack a heartbeat with the remaining embryos having a slower heartbeat (86 bpm vs 128 bpm)
• by E14.5 all embryos have lost their heartbeat
|
embryo
|
|
• at E12.5, some yolk sacs are poorly perfused while others are devoid of blood
|
hematopoietic system
|
|
• mice have normal amounts of erthyrocytes and do not display other signs of anemia
|
homeostasis/metabolism
muscle
|
|
• by E12.5, the myocardium of is only 1-2 cell layers thick compared to a thickness of 5 cell layers or more in littermate controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf2tm1Mlkn mutation
(0 available);
any
Klf2 mutation
(12 available)
Tg(VAV1-cre)1Graf mutation
(1 available)
|
|
|
immune system
|
|
• mice lack T cells in the peripheral blood
|
hematopoietic system
|
|
• mice lack T cells in the peripheral blood
|
Analysis Tools