All Phenotypes Nr5a2<tm1Sjns> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr5a2^tm1Sjns
targeted mutation 1, Kristina Schoonjans
MGI:3720193

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Nr5a2^tm1Sjns/Nr5a2^tm1Sjns	involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:3769251
cn2	Ldlr^tm1Her/Ldlr^tm1Her Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA	MGI:5607406
cn3	Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Tg(Vil1-cre/ERT2)23Syr/?	involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:3721528

Allelic Composition	Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Nr5a2^tm1Sjns/Nr5a2^tm1Sjns
Genetic Background	involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alb^{tm1(cre/ERT2)Mtz} mutation (1 available); any Alb mutation (91 available)
Nr5a2^tm1Sjns mutation (0 available); any Nr5a2 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal intestinal lipid absorption ( J:129068 )

• following treatment with tamoxifen, mice exhibit lipid malabsorption

abnormal bile salt level ( J:129068 )

• following treatment with tamoxifen, the bile acid pool size is reduced as is the levels in the livers /gallbladders and intestines due to a reduction in cholic acid and tauroconjugated cholic acid while the levels of muricholic acid, ursodeoxycholic acid and their taurine conjugates are increased

increased bile salt level ( J:129068 )

• following treatment with tamoxifen, bile acid in the feces is almost doubled in Nr5a2^tm2Sjns homozygotes due to an increase in lithocholic acid and hydrophobic secondary bile acids produced in the intestine by bacteria

digestive/alimentary system

abnormal intestinal lipid absorption ( J:129068 )

• following treatment with tamoxifen, mice exhibit lipid malabsorption

abnormal feces composition ( J:129068 )

• following treatment with tamoxifen, feces lipid and bile acid content is increased

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)
Nr5a2^tm1Sjns mutation (0 available); any Nr5a2 mutation (94 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:215556 )

N	• mice fed a high-cholesterol diet for 12 weeks exhibit a similar body and liver weight as single Ldlr homozygotes and do not develop increased atherosclerosis

digestive/alimentary system

abnormal feces composition ( J:215556 )

• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygote

homeostasis/metabolism

abnormal sterol level ( J:215556 )

• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygotes

Allelic Composition	Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Tg(Vil1-cre/ERT2)23Syr/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a2^tm1Sjns mutation (0 available); any Nr5a2 mutation (94 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

colonic necrosis ( J:123697 )

• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis results in severe lesions with advanced necrosis

increased susceptibility to induced colitis ( J:123697 )

• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis is more severe than in wild-type mice

immune system

increased susceptibility to induced colitis ( J:123697 )

• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis is more severe than in wild-type mice

cellular

colonic necrosis ( J:123697 )

• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis results in severe lesions with advanced necrosis

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