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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cdh5-cre/ERT2)CIVE23Mlia
transgene insertion CIVE23, M Luisa Iruela-Arispe
MGI:3700149
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Tg(TRAMP)8247Ng/0 		involves: 129X1/SvJ * C57BL/6 * C57BL/6J MGI:5477818
cn2
 		Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 		involves: 129X1/SvJ * C57BL/6J MGI:5477817


Genotype
MGI:5477818
cn1
Allelic
Composition		 Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Tg(TRAMP)8247Ng/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation (0 available); any Epn1 mutation (32 available)
Epn2tm1Ocr mutation (0 available); any Epn2 mutation (73 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)
Tg(TRAMP)8247Ng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0 mice

mortality/aging
increased tumor-free survival time ( J:193966 )
• tamoxifen-treated mice exhibit decreased mortality compared with Tg(TRAMP)8247Ng control mice

neoplasm
decreased tumor growth/size ( J:193966 )
• tamoxifen-treated mice develop smaller tumors compared with Tg(TRAMP)8247Ng control mice




Genotype
MGI:5477817
cn2
Allelic
Composition		 Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation (0 available); any Epn1 mutation (32 available)
Epn2tm1Ocr mutation (0 available); any Epn2 mutation (73 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Disrupted endothelial junctions in tumor vessels of Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 mice

mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:193966 )
• tamoxifen-treated mice transplanted with GL261glioma cells survive longer than with control mice

neoplasm
abnormal tumor vascularization ( J:193966 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice
• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature
decreased incidence of tumors by chemical induction ( J:193966 )
• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice
decreased tumor growth/size ( J:193966 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer, smaller tumors that grow at a slower rate compared with control mice
• tamoxifen-treated mice transplanted with GL261glioma cells develop smaller tumors compared with control mice
• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

cardiovascular system
abnormal tumor vascularization ( J:193966 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice
• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature
abnormal vascular endothelial cell migration ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells
abnormal vascular endothelial cell physiology ( J:193966 )
• endothelial cells treated with tamoxifen exhibit disrupted endothelial junctions compared with control cells
increased vascular endothelial cell proliferation ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells
increased vascular permeability ( J:193966 )
• of tumor vasculature in tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells
• however, vascular permeability of blood vessels in major organs is normal

cellular
abnormal vascular endothelial cell migration ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells
increased vascular endothelial cell proliferation ( J:193966 )
• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:193966 )
• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory