All Phenotypes Tg(Cdh5-cre/ERT2)CIVE23Mlia MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Med23^tm1Gwan/Med23^tm1Gwan Tg(Cdh5-cre/ERT2)CIVE23Mlia/0	involves: 129 * C57BL/6J	MGI:8315518
cn2	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:5477818
cn3	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0	involves: 129X1/SvJ * C57BL/6J	MGI:5477817

Allelic Composition	Med23^tm1Gwan/Med23^tm1Gwan Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med23^tm1Gwan mutation (0 available); any Med23 mutation (75 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased angiogenesis ( J:324181 )

• in vivo retinal angiogenesis assays show that mice injected with tamoxifen from P1 to P3 exhibit significantly reduced numbers of tip cells and filopodia at the edge of the vascular network in retinal tissues at P5

• at P5, PECAM staining shows a reduction in vascular network density as well as a decreased staining signal suggesting reduced levels of PECAM protein in retinal vessels

Allelic Composition	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1^tm1.1Wami mutation (0 available); any Epn1 mutation (33 available)
Epn2^tm1Ocr mutation (0 available); any Epn2 mutation (73 available)
Tg(Cdh5-cre/ERT2)CIVE23Mlia mutation (0 available)
Tg(TRAMP)8247Ng mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced tumor growth in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0 mice

mortality/aging

increased tumor-free survival time ( J:193966 )

• tamoxifen-treated mice exhibit decreased mortality compared with Tg(TRAMP)8247Ng control mice

neoplasm

decreased tumor growth/size ( J:193966 )

• tamoxifen-treated mice develop smaller tumors compared with Tg(TRAMP)8247Ng control mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Disrupted endothelial junctions in tumor vessels of Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 mice

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:193966 )

• tamoxifen-treated mice transplanted with GL261glioma cells survive longer than with control mice

neoplasm

abnormal tumor vascularization ( J:193966 )

• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice

• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature

decreased incidence of tumors by chemical induction ( J:193966 )

• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

decreased tumor growth/size ( J:193966 )

• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer, smaller tumors that grow at a slower rate compared with control mice

• tamoxifen-treated mice transplanted with GL261glioma cells develop smaller tumors compared with control mice

• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

cardiovascular system

abnormal tumor vascularization ( J:193966 )

• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit disorganized, fragile, immature, enlarged and leaky tumor vessels compared with control mice

• however, treatment with a VEGFR2 kinase inhibitor restored tumor vasculature

abnormal vascular endothelial cell migration ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells

abnormal vascular endothelial cell physiology ( J:193966 )

• endothelial cells treated with tamoxifen exhibit disrupted endothelial junctions compared with control cells

increased vascular endothelial cell proliferation ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells

increased vascular permeability ( J:193966 )

• of tumor vasculature in tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells

• however, vascular permeability of blood vessels in major organs is normal

cellular

abnormal vascular endothelial cell migration ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated migration compared with control cells

increased vascular endothelial cell proliferation ( J:193966 )

• endothelial cells treated with tamoxifen exhibit enhanced VEGF-stimulated proliferation compared with control cells

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:193966 )

• tamoxifen-treated mice subjected to AOM/DSS exhibit reduced tumor incidence and decreased tumor growth compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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