Epn2tm1Ocr
Targeted Allele Detail
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Symbol: |
Epn2tm1Ocr |
Name: |
epsin 2; targeted mutation 1, Ottavio Cremona |
MGI ID: |
MGI:4356016 |
Gene: |
Epn2 Location: Chr11:61408075-61470513 bp, - strand Genetic Position: Chr11, 37.96 cM, cytoband B2
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Alliance: |
Epn2tm1Ocr page
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Major developmental defects in Epn1tm1Ocr/Epn1tm1Ocr Epn2tm1Ocr/Epn2tm1Ocr embryos
Show the 7 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:151951
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The 3' end of the first coding exon and the 5'end of the following intron were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in multiple tissues from homozygous mice.
(J:151951)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Epn2 Mutation: |
73 strains or lines available
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Original: |
J:151951 Chen H, et al., Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13838-43 |
All: |
9 reference(s) |
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