Analysis Tools
mortality/aging
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• homozygotes die around E10.5
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Allele Symbol Allele Name Allele ID |
Foxo1tm1.1Rdp targeted mutation 1.1, Ronald DePinho MGI:3698868 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes die around E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an accumulation of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• however, follicle B cells are rescued compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
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• mice exhibit an accumulation of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
• however, follicle B cells are rescued compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
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• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal body weight
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| N |
• mice exhibit normal osteocalcin serum levels
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| N |
• mice exhibit normal bone mass and osteoblast numbers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal osteocalcin serum levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early
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• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
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• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
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• serum luteinizing hormone levels are below the level of detection in tumor bearing mice
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• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early
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• 60% incidence of granulosa cell tumor occurrence, with early tumor development
• granulosa cell tumors are either solid and surrounded by a thin layer of ovarian tissue containing a few growing follicles or are larger and contain tubular-like structures of different sizes and shapes surrounded by a basal lamina of collagen IV
• mice injected with superovulatory levels of equine gonadotropin and human gonadotropin at 6 weeks of age develop large granulosa cell tumors early
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
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• in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
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• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts
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• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
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• serum levels of estradiol are elevated in tumor bearing mice
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• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
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• serum luteinizing hormone levels are below the level of detection in tumor bearing mice
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• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts
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• 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent
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• in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side
|
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• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
• 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ovarian cancer | DOID:2394 |
OMIM:167000 OMIM:607893 |
J:232961 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ovaries of 3-4 month old mice contain many small abnormal follicles in which fragmented oocytes or only remnants of the zona pellucida are evident
• some follicles in 3-4 month old mice assume the appearance of testicular-like structures
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• ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic
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• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
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• tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B
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|
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• serum levels of estradiol are elevated in tumor bearing mice
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|
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• serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice
|
|
|
• serum luteinizing hormone levels are below the level of detection in tumor bearing mice
|
|
|
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
|
|
|
• ovaries of 3-4 month old mice contain many small abnormal follicles in which fragmented oocytes or only remnants of the zona pellucida are evident
• some follicles in 3-4 month old mice assume the appearance of testicular-like structures
|
|
|
• ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic
|
|
|
• about 20% of mice develop granulosa cell tumors by 6-8 months of age
• most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures
• some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis
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• ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ovarian cancer | DOID:2394 |
OMIM:167000 OMIM:607893 |
J:232961 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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