Phenotypes associated with this allele

• Allele Symbol: Tg(Sim1-cre)1Lowl
• Allele Name: transgene insertion 1, Bradford B Lowell
• Allele ID: MGI:3692526
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817650
cn2	Rai1^tm2.1Luo/Rai1^+ Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)	MGI:5817653
cn3	Nr3c1^tm1.1Mvc/Nr3c1^+ Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB	MGI:5306344
cn4	Saraf^tm1c(KOMP)Wtsi/Saraf^tm1c(KOMP)Wtsi Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB	MGI:7537120
cn5	Nr3c1^tm1.1Mvc/Nr3c1^tm1.1Mvc Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB	MGI:5306343
cn6	Col1a1^tm8(CAG-BDNF)Jae/Col1a1^tm8(CAG-BDNF)Jae Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5306345
cn7	Crh^tm2.1Maj/Crh^tm2.1Maj Tg(Sim1-cre)1Lowl/?	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5823206
cn8	Mc4r^tm1Lowl/Mc4r^tm1Lowl Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJae * C57BL/6J * FVB	MGI:3692535
cn9	Mc4r^tm2Lowl/Mc4r^tm2Lowl Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609590
cn10	Mrap2^tm1.2Maj/Mrap2^tm1.2Maj Tg(Sim1-cre)1Lowl/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5526069

Genotype
MGI:5817650

cn1

• Allelic Composition: Rai1^tm2.1Luo/Rai1^tm2.1Luo; Tg(Sim1-cre)1Lowl/?
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased body fat mass ( J:237687 )

♀

increased total fat pad weight ( J:237687 )

♀ • increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT

behavior/neurological

behavior/neurological phenotype ( J:237687 )

♂N • males exhibit no motor weakness in wire hang test

polyphagia ( J:237687 )

♀ • hyperphagic with a 47% increase in average daily food intake

decreased locomotor activity ( J:237687 )

♂ • decreased horizontal locomotor activity

growth/size/body

increased body fat mass ( J:237687 )

♀

increased lean body mass ( J:237687 )

♀

obese ( J:237687 )

♀ • mice are 57% heavier than controls at 20 weeks of age

homeostasis/metabolism

increased cholesterol level ( J:237687 )

♀

increased circulating HDL cholesterol level ( J:237687 )

♀

increased circulating LDL cholesterol level ( J:237687 )

♀

increased circulating VLDL cholesterol level ( J:237687 )

♀

increased triglyceride level ( J:237687 )

♀

Genotype
MGI:5817653

cn2

• Allelic Composition: Rai1^tm2.1Luo/Rai1⁺; Tg(Sim1-cre)1Lowl/?
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

growth/size/body

increased body weight ( J:237687 )

♀ • females are 12.7% heavier than controls at 20 weeks of age

Genotype
MGI:5306344

cn3

• Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1⁺; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129 * C57BL/6 * FVB

growth/size/body

decreased body weight ( J:179918 )

• during adulthood

homeostasis/metabolism

increased circulating corticosterone level ( J:179918 )

increased circulating adrenocorticotropin level ( J:179918 )

nervous system

abnormal hypothalamus physiology ( J:179918 )

• elevated immunoreactivity for corticotropin-releasing hormone in the paraventricular nucleus

Genotype
MGI:7537120

cn4

• Allelic Composition: Saraf^{tm1c(KOMP)Wtsi}/Saraf^{tm1c(KOMP)Wtsi}; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129 * C57BL/6 * FVB
• Cell Lines: EPD0613_2_B07

growth/size/body

growth/size/body region phenotype ( J:337869 )

N • when fed a Western diet for 18 weeks, mice show no differences in total increase in body weight and composition relative to controls

increased lean body mass ( J:337869 )

• at 1 year, but not at 3 months, of age, percentage of lean mass is significantly higher than in control mice

decreased body weight ( J:337869 )

• at 1 year, but not at 3 months, of age, body weight is significantly lower than that in control mice

adipose tissue

adipose tissue phenotype ( J:337869 )

N • at 1 year of age, inguinal and visceral adipose tissues show no differences in WAT droplet size relative to control mice; lipid accumulation phenotype is unchanged in Western diet-fed mice

decreased brown adipose tissue amount ( J:337869 )

• at 1 year of age, intracapsular brown adipose tissue (iBAT) shows significantly less fat accumulation (pixels of fat droplets/area) than in control mice

decreased percent body fat/body weight ( J:337869 )

• at 1 year, but not at 3 months, of age, percentage of fat mass is significantly lower than in control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:337869 )

N • at 3 months of age, mice exhibit normal glucose tolerance relative to control mice

N • when fed a Western diet for 18 weeks, mice show normal glucose tolerance and no differences in calorimetry relative to controls

increased basal metabolism ( J:337869 )

• at 1 year of age, mice exhibit increased heat production over time and a significant increase in heat production per body weight

liver/biliary system

liver/biliary system phenotype ( J:337869 )

N • mice show no fat accumulation in the liver at 1 year of age

behavior/neurological

behavior/neurological phenotype ( J:337869 )

• at 1 year of age, total food intake is not significantly altered, either under basal or refeed-challenged conditions; refeed responses are also unchanged in Western diet-fed mice

• at 3 months of age, mice do not exhibit altered anxiety-related behavioral phenotypes

increased locomotor activity ( J:337869 )

• at 3 months and at 1 year of age, mice exhibit increased dark-phase locomotion, as indicated by the light beam breaks count

Genotype
MGI:5306343

cn5

• Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1^tm1.1Mvc; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129 * C57BL/6 * FVB

mortality/aging

lethality, complete penetrance ( J:179918 )

Genotype
MGI:5306345

cn6

• Allelic Composition: Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1^{tm8(CAG-BDNF)Jae}; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

nervous system

abnormal hypothalamus physiology ( J:179918 )

• elevated immunoreactivity for corticotropin-releasing hormone in the paraventricular nucleus

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179918 )

N • despite increase in corticotropin-releasing hormone levels in the paraventricular nucleus, circulating adrenocorticotropin and corticosterone are largely unaffected

Genotype
MGI:5823206

cn7

• Allelic Composition: Crh^tm2.1Maj/Crh^tm2.1Maj; Tg(Sim1-cre)1Lowl/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

behavior/neurological

decreased anxiety-related response ( J:238330 )

• mice spend increased time in center in open-field paradigm

• mice exhibit a shorter latency into both center and neutral areas in open-field paradigm

• entry into center of holeboard is increased

• increase in exploratory tendency and risky behavior in a new environment

• mice spend less time in closed arms and increased time in open arms of elevated plus maze

• mice exhibit a decreased latency to enter lit arms of light-dark box

• mice exhibit a preference for approaching a novel versus familiar object

• mice exhibit a longer exploratory duration around a novel object

endocrine/exocrine glands

decreased adrenal gland weight ( J:238330 )

adrenal gland atrophy ( J:238330 )

• adrenal atrophy especially in the zone fasciculata of the adrenal gland

abnormal adrenal gland secretion ( J:238330 )

• stress-induced plasma corticosterone release is two-thirds of controls

homeostasis/metabolism

decreased circulating corticosterone level ( J:238330 )

• decreased basal, diurnal, and stressor-stimulated plasma corticosterone secretion

decreased circulating adrenocorticotropin level ( J:238330 )

• decreased plasma adrenocorticotropic hormone

Genotype
MGI:3692535

cn8

• Allelic Composition: Mc4r^tm1Lowl/Mc4r^tm1Lowl; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

growth/size/body

growth/size/body region phenotype ( J:115192 )

N • at 12 weeks, transgenic mice and wild-type littermates have the same snout-anus length, compared to increased length observed in nontransgenic Mc4r^tm1Lowl mice

increased lean body mass ( J:115192 )

• transgenic mice have increased lean mass compared with wild-type littermates, but significantly decreased lean mass compared to Mc4r^tm1Lowl littermates

increased body weight ( J:115192 )

• transgenic mice have increased fat mass compared with wild-type littermates, but significantly decreased fat mass compared to Mc4r^tm1Lowl littermates

obese ( J:115192 )

• at 12 weeks of age, male and female mutants have only 37% and 46% respectively, of the obesity observed in mice homozygous for Mc4r disruption

homeostasis/metabolism

abnormal oxygen consumption ( J:115192 )

• mice do not show an increase in oxygen consumption from stimulation by MTII as wild-type mice do

decreased oxygen consumption ( J:115192 )

• oxygen consumption is reduced in the dark and light cycles compared to wild-type and is similar to Mc4r^tm1Lowl homozygotes

behavior/neurological

behavior/neurological phenotype ( J:115192 )

N • transgenic mice are obese, yet show food intake comparable to wild-type mice at 11 weeks of age

abnormal food intake ( J:115192 )

• when treated with MTII an Mc4r inhibitor, wild-type mice show a 50% reduction in food intake, while transgenic mice display no effect on intake

Genotype
MGI:5609590

cn9

• Allelic Composition: Mc4r^tm2Lowl/Mc4r^tm2Lowl; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

adipose tissue

increased total body fat amount ( J:216397 )

• increase in fat mass

behavior/neurological

polyphagia ( J:216397 )

growth/size/body

obese ( J:216397 )

increased body length ( J:216397 )

Genotype
MGI:5526069

cn10

• Allelic Composition: Mrap2^tm1.2Maj/Mrap2^tm1.2Maj; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N

growth/size/body

obese ( J:199365 )

• similar to global null mice

increased susceptibility to weight gain ( J:199365 )

• pair-feeding to a normal dietary intake only partially reverses obesity