All Phenotypes Mdm4<tm2.1Glo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mdm4^tm2.1Glo
targeted mutation 2.1, Guillermina Lozano
MGI:3612474

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm4^tm2.1Glo/Mdm4^tm2.1Glo	involves: 129S4/SvJaeSor * C57BL/6J	MGI:3616707
cn2	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * FVB/N	MGI:5907135
cn3	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53⁺	involves: 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:5907132
cn4	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3616711
cx5	Mdm4^tm2.1Glo/Mdm4^tm2.1Glo Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J	MGI:3616708
cx6	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm2.1Glo/Mdm4⁺	involves: 129S7/SvEvBrd	MGI:5140383

Allelic Composition	Mdm4^tm2.1Glo/Mdm4^tm2.1Glo
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm2.1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:104114 )

• stage not specified, however at E9.5, all embryos are abnormal

Allelic Composition	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm2.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Mdm4^tm2Glo mutation (1 available); any Mdm4 mutation (191 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:137114 )

• mice die due to tumors not heart failure

extended life span ( J:137114 )

• mice show an extended mean survival of 403 days compared to compound heterozygous Mdm4^tm2Glo/Mdm4^tm2.1Glo conditional mutants

cardiovascular system

cardiovascular system phenotype ( J:137114 )

N	• mice do not exhibit signs of heart failure such as edema and poor breathing and exhibit rescue of the dilated cardiomyopathy

neoplasm

increased tumor incidence ( J:137114 )

Allelic Composition	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm2.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Mdm4^tm2Glo mutation (1 available); any Mdm4 mutation (191 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:137114 )

• mice show an extended median survival of 274 days compared to compound heterozygous Mdm4^tm2Glo/Mdm4^tm2.1Glo conditional mutants

Allelic Composition	Mdm4^tm2Glo/Mdm4^tm2.1Glo Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:104114 , J:137114 )

• some mice die within 1 year for unknown reasons, however do not observe any embryonic lethality (J:104114)

• median survival of 208 and 243 days for males and females, respectively (J:137114)

• mice die as a result of heart failure (J:137114)

cellular

increased cardiomyocyte apoptosis ( J:137114 )

cardiovascular system

cardiovascular system phenotype ( J:104114 )

N	• no abnormalities in embryonic hearts are seen

decreased myocardial fiber number ( J:137114 )

• hearts exhibit half the number of cardiomyocytes at 8 months of age

increased myocardial fiber size ( J:137114 )

• marker analysis indicates cardiomyocyte hypertrophy

enlarged heart ( J:137114 )

thin ventricular wall ( J:137114 )

• ventricular walls are thinner and hypertrophic

dilated heart ventricle ( J:137114 )

• all 4 chambers are dilated and paler than control hearts

cardiac fibrosis ( J:137114 )

dilated cardiomyopathy ( J:137114 )

• severe dilated cardiomyopathy

increased cardiomyocyte apoptosis ( J:137114 )

congestive heart failure ( J:137114 )

• by 8-10 months of age, most mice have swollen bodies, have difficulty moving, and are out of breath

homeostasis/metabolism

edema ( J:137114 )

• edema in the lung and/or abdomen

muscle

decreased myocardial fiber number ( J:137114 )

• hearts exhibit half the number of cardiomyocytes at 8 months of age

increased myocardial fiber size ( J:137114 )

• marker analysis indicates cardiomyocyte hypertrophy

dilated cardiomyopathy ( J:137114 )

• severe dilated cardiomyopathy

increased cardiomyocyte apoptosis ( J:137114 )

growth/size/body

enlarged heart ( J:137114 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:137114

Allelic Composition	Mdm4^tm2.1Glo/Mdm4^tm2.1Glo Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm2.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:104114 )

• double homozygotes are viable and born at the expected ratio, exhibiting rescue of the embryonic lethality of single homozygous Mdm4 mice, however no further phenotypic analysis is reported

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm2.1Glo/Mdm4⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4^tm2.1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

increased foot pad pigmentation ( J:174216 )

• starting in early postnatal development

integument

increased foot pad pigmentation ( J:174216 )

• starting in early postnatal development

limbs/digits/tail

increased foot pad pigmentation ( J:174216 )

• starting in early postnatal development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23