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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(T-cre)1Lwd
transgene insertion 1, Mark Lewandoski
MGI:3605847
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd2bp2tm1.1Tbh/Cd2bp2tm1.1Tbh
Tg(T-cre)1Lwd/0
B6OlaHsd.Cg-Cd2bp2tm1.1Tbh Tg(T-cre)1Lwd MGI:6392048
cn2
Cited2tm1Bha/Cited2tm2Bha
Tg(T-cre)1Lwd/0
involves: 129 * C3H * C57BL/6 * SJL MGI:3804088
cn3
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(T-cre)1Lwd/0
involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1 MGI:3606231
cn4
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 MGI:5774469
cn5
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 MGI:5509195
cn6
Etv4tm1Arbr/Etv4+
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:3849055
cn7
Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:3849054
cn8
Nodaltm1.1Mku/Nodaltm2Mku
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * C3H * C57BL/6 MGI:3830291
cn9
Zic3tm2.1Jwb/Y
Tg(T-cre)1Lwd/0
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C3H * C57BL/6 MGI:5470172
cn10
Rpl10atm1c(EUCOMM)Hmgu/Rpl10atm1c(EUCOMM)Hmgu
Tg(T-cre)1Lwd/0
involves: 129S4/SvJaeSor * C3H * C57BL/6N MGI:7385105
cn11
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:3607121
cn12
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:3606230
cn13
Eomestm1Rob/Eomestm1.1Rob
Tg(T-cre)1Lwd/0
involves: 129S/SvEv * C3H * C57BL/6 * CBA MGI:3775734
cn14
Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0
involves: C3H * C57BL/6 MGI:5476844
cn15
Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sor+
Tg(T-cre)1Lwd/0
involves: C3H * C57BL/6 * C57BL/6J MGI:5498472
cn16
Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan
Tg(T-cre)1Lwd/0
involves: C3H * C57BL/6 * C57BL/6J MGI:5498473


Genotype
MGI:6392048
cn1
Allelic
Composition
Cd2bp2tm1.1Tbh/Cd2bp2tm1.1Tbh
Tg(T-cre)1Lwd/0
Genetic
Background
B6OlaHsd.Cg-Cd2bp2tm1.1Tbh Tg(T-cre)1Lwd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd2bp2tm1.1Tbh mutation (0 available); any Cd2bp2 mutation (22 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• delayed vasculatization

cardiovascular system
• delayed vasculatization




Genotype
MGI:3804088
cn2
Allelic
Composition
Cited2tm1Bha/Cited2tm2Bha
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129 * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (19 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (19 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 3 of 14 mice exhibit defective cardiac septation and 1 of 14 mice exhibit abnormal left-right patterning
• both the aorta and the pulmonary trunk arise from the right ventricle
• common atrium created by complete absence of the primary atrial septum
• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
• in few mice
• dextral left ventricle

respiratory system

endocrine/exocrine glands
• in 10 of 14 mice

growth/size/body
• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum




Genotype
MGI:3606231
cn3
Allelic
Composition
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (12 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (12 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die shortly after birth

renal/urinary system
• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
• no glomeruli are present at any stage of kidney development
• at E14.5 mutant kidneys show only condensation and renal vesicle formation and not tubulogenesis or glomerulogenesis that are seen in wild-type mice
• at E16.5 evidence of cap formation is mostly missing and few vesicles remain in the mutant kidneys and those remaining vesicles do not show signs of tubulogenesis
• at E18.5 the hypocellular kidney is largely devoid of nephron epithelia
• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
• at E18.5 the few remaining ureteric bud radii fail to bifurcate in the cortical nephrogenic region; however, somite formation, tendon progenitor populations fro E10.5 - E14.5, and limb bud induction are normal
• at E14.5 ureteric bud branching is dramatically reduced

limbs/digits/tail
• most mutants lack at least one hindlimb digit; however, limb bud induction is normal

skeleton
N
• no defects are seen in skeletal development including rib formation

cellular
• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia




Genotype
MGI:5774469
cn4
Allelic
Composition
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation (0 available); any Gt(ROSA)26Sor mutation (795 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• 33% of mutants show fusion of ribs in the thoracic region
• neonates show vertebral malformations with a higher penetrance at the cervical level than at thoracic and lumber regions
• reduction in the number of thoracic vertebrae (12 instead of 13)
• absence of the tuberculum anterior on C6
• some mutants only have five lumbar vertebrae instead of six
• cervical regions show malformed neural arches
• neonates show vertebral fusions with a higher penetrance at the cervical level than at thoracic and lumber regions
• cervical vertebra 1 and associated anterior arch of the atlas are fused to the basioccipital bone
• neonates show the presence of a high number of homeotic transformations
• C2/C3 are anteriorly transformed
• cervical regions show anterior homeotic transformations




Genotype
MGI:5509195
cn5
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (42 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (42 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• severely truncated at E8.5
• at E8.5, somites are disorganized




Genotype
MGI:3849055
cn6
Allelic
Composition
Etv4tm1Arbr/Etv4+
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (32 available)
Etv5tm1.1Xsun mutation (2 available); any Etv5 mutation (270 available)
Etv5tm1.2Xsun mutation (0 available); any Etv5 mutation (270 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• in 6 of 8 mice




Genotype
MGI:3849054
cn7
Allelic
Composition
Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (32 available)
Etv5tm1.1Xsun mutation (2 available); any Etv5 mutation (270 available)
Etv5tm1.2Xsun mutation (0 available); any Etv5 mutation (270 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth due to internal organ defects

limbs/digits/tail
• limb buds exhibit reduced cell death compared to in wild-type mice
• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal
• however, forelimbs are normal

embryo
• limb buds exhibit reduced cell death compared to in wild-type mice

skeleton
• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice




Genotype
MGI:3830291
cn8
Allelic
Composition
Nodaltm1.1Mku/Nodaltm2Mku
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S1/Sv * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1.1Mku mutation (0 available); any Nodal mutation (38 available)
Nodaltm2Mku mutation (1 available); any Nodal mutation (38 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• the direction of looping is reversed in about half of the embryos at E8.5 - E9.5

embryo
N
• unlike in mice heterozygous for Nodal tm1Mku and Nodal tm1.1Mku, no midline or anterior/head morphological defects are detected
• expression analysis indicates complete loss of asymmetric signals in the lateral plate mesoderm

growth/size/body

hematopoietic system
• small or absent
• small or absent

immune system
• small or absent
• small or absent

respiratory system




Genotype
MGI:5470172
cn9
Allelic
Composition
Zic3tm2.1Jwb/Y
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation (1 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning

cardiovascular system
• in 4 of 22 mice

limbs/digits/tail

growth/size/body
• laterality defects in 4 of 18 mice




Genotype
MGI:7385105
cn10
Allelic
Composition
Rpl10atm1c(EUCOMM)Hmgu/Rpl10atm1c(EUCOMM)Hmgu
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S4/SvJaeSor * C3H * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl10atm1c(EUCOMM)Hmgu mutation (0 available); any Rpl10a mutation (62 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• mice exhibit normal posterior trunk




Genotype
MGI:3607121
cn11
Allelic
Composition
Fgfr1tm3.1Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.1Cxd mutation (0 available); any Fgfr1 mutation (207 available)
Fgfr1tm3.2Cxd mutation (0 available); any Fgfr1 mutation (207 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
• at E9.5 the open neural plate is expanded
• somite size is irregular

limbs/digits/tail
• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
• the forelimb autopod has only 3 digits 1 with 3 phalanges and 2 with 2 phalanges
• at E17.5, the stylopod is shortened by about 15%
• at E17.5, the zeugopod is reduced by about 12% and often fused at the distal end
• the hindlimb is more severely affected than the forelimb

nervous system
• at E9.5 the open neural plate is expanded

skeleton
• at E17.5 the initial cartilage condensations in the forelimb are reduced in number and size




Genotype
MGI:3606230
cn12
Allelic
Composition
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.2Cxd mutation (0 available); any Fgfr1 mutation (207 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
• at E9.5 the open neural plate is expanded
• somite size is irregular

limbs/digits/tail
• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
• the forelimb autopod has only 3 digits 1 with 3 phalanges and 2 with 2 phalanges
• at E17.5, the stylopod is shortened by about 15%
• at E17.5, the zeugopod is reduced by about 12% and often fused at the distal end
• the hindlimb is more severely affected than the forelimb

nervous system
• at E9.5 the open neural plate is expanded

skeleton
• at E17.5 the initial cartilage condensations in the forelimb are reduced in number and size




Genotype
MGI:3775734
cn13
Allelic
Composition
Eomestm1Rob/Eomestm1.1Rob
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S/SvEv * C3H * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Rob mutation (0 available); any Eomes mutation (32 available)
Eomestm1Rob mutation (0 available); any Eomes mutation (32 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• Mendelian numbers of conditionally null embryos are recovered around E6.5




Genotype
MGI:5476844
cn14
Allelic
Composition
Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation (1 available)
Zic3tm1.1Smwa mutation (0 available); any Zic3 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• similar to germ line null mice

cardiovascular system
• defects in looping similar to those in germ line null mice are seen at E10.5 and E13.5




Genotype
MGI:5498472
cn15
Allelic
Composition
Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sor+
Tg(T-cre)1Lwd/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fan mutation (0 available); any Gt(ROSA)26Sor mutation (795 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cervical vertebrae fusions in Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sor+ Tg(T-cre)1Lwd/0 mice

skeleton
• seen in approximately 40% of adults




Genotype
MGI:5498473
cn16
Allelic
Composition
Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan
Tg(T-cre)1Lwd/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fan mutation (0 available); any Gt(ROSA)26Sor mutation (795 available)
Tg(T-cre)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Skeletal defects in Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan Tg(T-cre)1Lwd/0 mice

mortality/aging

embryo
• at E8.5 somite lose their compact epithelial morphology, instead cells display a scattered pattern
• poorly defined boundaries are seen along the body axis at E8.75
• lack well separated epithelia at E9.5
• at E11.5 long stretches of mesenchymal patches that fail to segregate into repeated intervals are seen

nervous system
• axon bundles are not properly spaced

skeleton
• conspicuously defective along the cervical, trunk, and lumbar regions and to a lesser extent in the tail
• loss of intervertebral disks
• fusions of the neural arches and vertebral bodies

limbs/digits/tail
• in neonates

behavior/neurological
• straightened posture in neonates





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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory