Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
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normal phenotype
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• homozygous mice display no phenotypic abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
Tg(LGB-cre)74Acl mutation
(2 available)
Zfp157Gt(XC356)Byg mutation
(0 available);
any
Zfp157 mutation
(24 available)
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reproductive system
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N |
• rescue of the lactation failure seen in mutant mice wild-type for Zfp157
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integument
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• mild epithelial dysplasia in all ducts and alveoli with an increase in the number of binucleate cells and cells of variable sizes
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endocrine/exocrine glands
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• mild epithelial dysplasia in all ducts and alveoli with an increase in the number of binucleate cells and cells of variable sizes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation
(0 available);
any
Bhlhe22 mutation
(12 available)
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
Gata3tm2Gsv mutation
(0 available);
any
Gata3 mutation
(31 available)
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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nervous system
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• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
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• partial rescue of synaptic defects observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
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hearing/vestibular/ear
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• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation
(0 available);
any
Bhlhe22 mutation
(12 available)
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
Tg(Tnfrsf4-cre)1Nik mutation
(0 available)
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hematopoietic system
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• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection
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• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection
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• very little IgE in the serum in response to Nippostrongylus brasiliensis infection
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immune system
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• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection
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• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection
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• very little IgE in the serum in response to Nippostrongylus brasiliensis infection
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• failed to expel worms after Nippostrongylus brasiliensis infection
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
Tg(LGB-cre)74Acl mutation
(2 available)
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integument
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• very few expanded alveoli are seen
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• pups show little milk in their stomachs and are severely dehydrated
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endocrine/exocrine glands
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• very few expanded alveoli are seen
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• pups show little milk in their stomachs and are severely dehydrated
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• when mutant bone marrow cells are transferred to mice lacking surface expression of MHC I, the single positive T cell population in the thymus is composed of small numbers of CD8+ T cells instead of large numbers of CD4+ T cells
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• substantially decreased numbers of CD4+ single positive cells but normal numbers of CD8+ single positive cells
• CD4+ cells found in the lymph nodes had an activated or memory-like phenotype
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• the number of TCRhi CD4 thymocytes is much smaller (0.2 x 106) than in their wild-type counterparts (10.9 x 106)
• the number of CD4 T cells found in the periphery is very small and all have a memory phenotype suggesting they are descendents of an even smaller progenitor pool
• CD4 T cells are virtually absent in the spleen of 1 week old mice, giving further evidence that CD4 T cell population in adults results from expansion of a small progenitor pool
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hematopoietic system
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• when mutant bone marrow cells are transferred to mice lacking surface expression of MHC I, the single positive T cell population in the thymus is composed of small numbers of CD8+ T cells instead of large numbers of CD4+ T cells
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• substantially decreased numbers of CD4+ single positive cells but normal numbers of CD8+ single positive cells
• CD4+ cells found in the lymph nodes had an activated or memory-like phenotype
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• the number of TCRhi CD4 thymocytes is much smaller (0.2 x 106) than in their wild-type counterparts (10.9 x 106)
• the number of CD4 T cells found in the periphery is very small and all have a memory phenotype suggesting they are descendents of an even smaller progenitor pool
• CD4 T cells are virtually absent in the spleen of 1 week old mice, giving further evidence that CD4 T cell population in adults results from expansion of a small progenitor pool
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation
(0 available);
any
Gata3 mutation
(31 available)
Tg(Fev-cre)1Esd mutation
(1 available)
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nervous system
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• decrease in the number of Tph immunoreactive cells in the dorsal Raphe nucleus
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homeostasis/metabolism
immune system
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• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage
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hematopoietic system
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• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage
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Analysis Tools
