Gata3^tm2Gsv
Targeted Allele Detail

Summary

• Symbol: Gata3^tm2Gsv
• Name: GATA binding protein 3; targeted mutation 2, Frank Grosveld
• MGI ID: MGI:2181201
• Synonyms: Gata3^taulacZ, GATA-3^taulacZ
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm2Gsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77126
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing PGK-hygro tau-lacZ was inserted at the translational start codon in exon 2. The majority of exon 2 was deleted. (J:77126)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 31 strains or lines available

Notes

ES cell line = AB1 (129S7/SvEvBrd-Hprt⁺) or E14 (129P2/OlaHsd).

References

• Original: J:77126 van Doorninck JH, et al., GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. J Neurosci. 1999 Jun 15;19(12):RC12
• All: 9 reference(s)