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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(DTA)Riet
targeted mutation 1, Dieter Riethmacher
MGI:3055489
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet involves: 129P2/OlaHsd MGI:3653837
cn2
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Alb1-cre)7Gsc/0 		involves: 129P2/OlaHsd MGI:3055675
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd MGI:3055676
cn4
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Neurod6tm1(cre)Kan/Neurod6+ 		involves: 129P2/OlaHsd MGI:3055716
cn5
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Cnptm1(cre)Kan/Cnp+ 		involves: 129P2/OlaHsd MGI:3055718
cn6
 		En1tm2(cre)Gld/En1+
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:3839921
cn7
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365611
cn8
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365612
cn9
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Trp73tm1(cre)Agof/Trp73+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365609
cn10
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365610
cn11
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1tm1.1(cre)Uboe/Kiss1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J MGI:5052335
cn12
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL MGI:5052332
cn13
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:5524047
cx14
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Tg(Rorc-cre)1Litt/? 		involves: 129P2/OlaHsd MGI:3829422


Genotype
MGI:3653837
hm1
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:110983 )
• 40% died at 4 weeks of age
• none survived for over 1 year

limbs/digits/tail
vestigial tail ( J:110983 )
• degeneration of tail in older animal

vision/eye
increased susceptibility to age-related retinal degeneration ( J:110983 )
• retina degeneration in older animal which became more severe with increasing age

skeleton
abnormal skeleton morphology ( J:110983 )
• in older animal which became more severe with increasing age




Genotype
MGI:3055675
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Alb1-cre)7Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating alanine transaminase level ( J:92789 )
• consistent with the liver damage seen, ALT levels are increased 5-7 fold
increased circulating aspartate transaminase level ( J:92789 )
• consistent with the liver damage seen, AST levels are increased 5-7 fold

liver/biliary system
liver degeneration ( J:92789 )
• increased liver cell death is seen in 6 week old double hemizygotes




Genotype
MGI:3055676
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:92789 )
• B cell but not T cell numbers are reduced in the bone marrow and spleen to 65% and 50% of control, respectively
• B cell turn over is also increased in double mutants

immune system
decreased B cell number ( J:92789 )
• B cell but not T cell numbers are reduced in the bone marrow and spleen to 65% and 50% of control, respectively
• B cell turn over is also increased in double mutants




Genotype
MGI:3055716
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:92789 )
• mutants are born alive but die within the first day

nervous system
abnormal cerebral cortex morphology ( J:92789 )
• at E14.5, large numbers of apoptotic cells can be seen in the cre-expressing neuronal layer, in contrast no apoptotic cells are seen in controls
• at E16.5, the cortex is filled with many apoptotic cells and at E18.5 the cortex is highly degenerated and thin with abnormal layering and a wavelike structure




Genotype
MGI:3055718
cn5
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Cnptm1(cre)Kan/Cnp+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (29 available)
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:92789 )
• double mutants die between P12 and P14

behavior/neurological
tremors ( J:92789 )
• double mutants develop tremors around P8-10
paraparesis ( J:92789 )
• double mutants develop hindlimb weakness around P8-10

growth/size/body
weight loss ( J:92789 )
• around P8-10 double mutants begin to lose weight

nervous system
absent oligodendrocytes ( J:92789 )
• from P0 to P14, no oligodendrocytes can be detected in double mutants
axon degeneration ( J:92789 )
• large clusters of unmyelinated axons that show signs of degeneration and are not surrounded by Schwann cells are seen
demyelination ( J:92789 )
• loss of oligodendrocytes and a subset of Schwann cells results in a dramatic decrease in the number of myelinated fibers in the nerves and large clusters of unmyelinated axons are seen

cellular
absent oligodendrocytes ( J:92789 )
• from P0 to P14, no oligodendrocytes can be detected in double mutants




Genotype
MGI:3839921
cn6
Allelic
Composition		 En1tm2(cre)Gld/En1+
Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Gld mutation (0 available); any En1 mutation (34 available)
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal ventral interneuron 1 morphology ( J:106437 )
• decrease in the number of V1 neurons in the spinal cord
abnormal CNS synaptic transmission ( J:106437 )
• significant increase in the length of both step cycle period and motor neuron burst duration during fictive locomotion




Genotype
MGI:4365611
cn7
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 35% at P0




Genotype
MGI:4365612
cn8
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (47 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated




Genotype
MGI:4365609
cn9
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced




Genotype
MGI:4365610
cn10
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 72% at P0




Genotype
MGI:5052335
cn11
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Kiss1tm1.1(cre)Uboe mutation (0 available); any Kiss1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:173936 )
N
• mice are viable

reproductive system
reproductive system phenotype ( J:173936 )
N
• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile
abnormal vagina development ( J:173936 )
• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice

growth/size/body
increased body weight ( J:173936 )
• slightly increased in female mice between P31 and P46

endocrine/exocrine glands




Genotype
MGI:5052332
cn12
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Kiss1rtm1.1(cre)Uboe/Kiss1r+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Kiss1rtm1.1(cre)Uboe mutation (0 available); any Kiss1r mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173936 )
N
• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile
abnormal vagina development ( J:173936 )
• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice

nervous system
decreased neuron number ( J:173936 )
• the number of gonadotrophin-releasing hormone neurons in the hypothalamus of female mice is decreased compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:5524047
cn13
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Tg(Pomc-EGFP)1Low/0
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
decreased uterus weight ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons

adipose tissue
increased abdominal adipose tissue amount ( J:199640 )
• increased visceral fat mass
• however, subcutaneous adipose weight is normal

endocrine/exocrine glands
small ovary ( J:199640 )
• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice




Genotype
MGI:3829422
cx14
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sortm1(DTA)Riet
Tg(Rorc-cre)1Litt/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory