Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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mortality/aging
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• 40% died at 4 weeks of age
• none survived for over 1 year
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limbs/digits/tail
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• degeneration of tail in older animal
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vision/eye
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• retina degeneration in older animal which became more severe with increasing age
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skeleton
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• in older animal which became more severe with increasing age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Alb1-cre)7Gsc mutation
(1 available)
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homeostasis/metabolism
liver/biliary system
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• increased liver cell death is seen in 6 week old double hemizygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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hematopoietic system
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• B cell but not T cell numbers are reduced in the bone marrow and spleen to 65% and 50% of control, respectively
• B cell turn over is also increased in double mutants
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immune system
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• B cell but not T cell numbers are reduced in the bone marrow and spleen to 65% and 50% of control, respectively
• B cell turn over is also increased in double mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Neurod6tm1(cre)Kan mutation
(0 available);
any
Neurod6 mutation
(17 available)
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mortality/aging
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• mutants are born alive but die within the first day
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nervous system
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• at E14.5, large numbers of apoptotic cells can be seen in the cre-expressing neuronal layer, in contrast no apoptotic cells are seen in controls
• at E16.5, the cortex is filled with many apoptotic cells and at E18.5 the cortex is highly degenerated and thin with abnormal layering and a wavelike structure
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation
(0 available);
any
Cnp mutation
(26 available)
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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mortality/aging
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• double mutants die between P12 and P14
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behavior/neurological
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• double mutants develop tremors around P8-10
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• double mutants develop hindlimb weakness around P8-10
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growth/size/body
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• around P8-10 double mutants begin to lose weight
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nervous system
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• from P0 to P14, no oligodendrocytes can be detected in double mutants
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• large clusters of unmyelinated axons that show signs of degeneration and are not surrounded by Schwann cells are seen
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• loss of oligodendrocytes and a subset of Schwann cells results in a dramatic decrease in the number of myelinated fibers in the nerves and large clusters of unmyelinated axons are seen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Gld mutation
(0 available);
any
En1 mutation
(32 available)
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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nervous system
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• decrease in the number of V1 neurons in the spinal cord
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• significant increase in the length of both step cycle period and motor neuron burst duration during fictive locomotion
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Relnrl mutation
(3 available);
any
Reln mutation
(209 available)
Wnt3atm1(cre)Eag mutation
(0 available);
any
Wnt3a mutation
(25 available)
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nervous system
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• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 35% at P0
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Relnrl mutation
(3 available);
any
Reln mutation
(209 available)
Trp73tm1(cre)Agof mutation
(0 available);
any
Trp73 mutation
(42 available)
Wnt3atm1(cre)Eag mutation
(0 available);
any
Wnt3a mutation
(25 available)
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nervous system
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• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Trp73tm1(cre)Agof mutation
(0 available);
any
Trp73 mutation
(42 available)
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nervous system
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• number of Cajal-Retzius cells in the cortical marginal zone is reduced
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Relnrl mutation
(3 available);
any
Reln mutation
(209 available)
Trp73tm1(cre)Agof mutation
(0 available);
any
Trp73 mutation
(42 available)
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nervous system
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• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 72% at P0
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Kiss1tm1.1(cre)Uboe mutation
(0 available);
any
Kiss1 mutation
(21 available)
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mortality/aging
reproductive system
N |
• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile
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• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice
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growth/size/body
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• slightly increased in female mice between P31 and P46
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endocrine/exocrine glands
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Kiss1rtm1.1(cre)Uboe mutation
(0 available);
any
Kiss1r mutation
(20 available)
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reproductive system
N |
• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile
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• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice
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nervous system
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• the number of gonadotrophin-releasing hormone neurons in the hypothalamus of female mice is decreased compared to in wild-type mice
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endocrine/exocrine glands
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Gnrh1-cre)1Dlc mutation
(1 available)
Tg(Pomc-EGFP)1Low mutation
(1 available)
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reproductive system
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• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
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• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
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nervous system
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• severe reduction in Pomc+ neurons
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adipose tissue
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• increased visceral fat mass
• however, subcutaneous adipose weight is normal
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endocrine/exocrine glands
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• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Rorc-cre)1Litt mutation
(1 available)
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hematopoietic system
immune system