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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grem1tm1Rmh
targeted mutation 1, Richard M Harland
MGI:3054923
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grem1tm1Rmh/Grem1tm1Rmh involves: 129P2/OlaHsd MGI:3700692
hm2
 		Grem1tm1Rmh/Grem1tm1Rmh involves: 129P2/OlaHsd * C57BL/6 MGI:3055029
cn3
 		Grem1tm1Ecan/Grem1tm1Rmh
Tg(BGLAP-cre)1Clem/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N MGI:3761936
cx4
 		Grem1tm1Rmh/Grem1+
Rr26tm1Svok/Rr26+ 		involves: 129P2/OlaHsd * 129X1/SvJ MGI:5562301


Genotype
MGI:3700692
hm1
Allelic
Composition		 Grem1tm1Rmh/Grem1tm1Rmh
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Rmh mutation (1 available); any Grem1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:130204 )
N
• bladder neck-urethra angle is same as in wild-type embryos

reproductive system
reproductive system phenotype ( J:130204 )
N
• budding pattern of developing prostate is identical to wild-type embryos several days after initiation of prostatic budding




Genotype
MGI:3055029
hm2
Allelic
Composition		 Grem1tm1Rmh/Grem1tm1Rmh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Rmh mutation (1 available); any Grem1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:84077 )
• die within 48 hrs of birth

limbs/digits/tail
oligodactyly ( J:84077 )
• fewer digits than normal
syndactyly ( J:84077 )
• abnormal maintainance of interdigital tissue
• soft tissue syndactyly
abnormal forelimb morphology ( J:84077 )
• lower forelimb initially normal but radius and ulna fuse later
abnormal hindlimb morphology ( J:84077 )
• only one bone in lower hind limb

renal/urinary system




Genotype
MGI:3761936
cn3
Allelic
Composition		 Grem1tm1Ecan/Grem1tm1Rmh
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Ecan mutation (0 available); any Grem1 mutation (16 available)
Grem1tm1Rmh mutation (1 available); any Grem1 mutation (16 available)
Tg(BGLAP-cre)1Clem mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
enhanced osteoblast differentiation ( J:126375 )
• in vitro osteoblast maturation is enhanced
increased trabecular bone volume ( J:126375 )
• 40% increase in trabecular bone volume due to increased bone thickness
increased bone mineralization ( J:126375 )
• the mineral apposition rate is enhanced
increased bone ossification ( J:126375 )
• bone formation rate is 2.5 fold higher than in littermate controls

cellular
enhanced osteoblast differentiation ( J:126375 )
• in vitro osteoblast maturation is enhanced




Genotype
MGI:5562301
cx4
Allelic
Composition		 Grem1tm1Rmh/Grem1+
Rr26tm1Svok/Rr26+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Rmh mutation (1 available); any Grem1 mutation (16 available)
Rr26tm1Svok mutation (0 available); any Rr26 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:207959 )
N
• mice exhibit normal skeletal patterning




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory