All Phenotypes Tg(BCL2)22Wehi MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(BCL2)22Wehi
transgene insertion 22, Walter and Eliza Hall Institute of Medical Research
MGI:3052827

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺ Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Tg(BCL2)22Wehi/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi	MGI:5568509
cn2	Cd79a^tm1(cre)Reth/Cd79a⁺ Dicer1^tm1Mmk/Dicer1^tm1Mmk Tg(BCL2)22Wehi/0	involves: BALB/c * C57BL/6JWehi * SJL/JWehi	MGI:3797395
cx3	Cd72^tm1Jrp/Cd72^tm1Jrp Tg(BCL2)22Wehi/0	either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)	MGI:3700223
cx4	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(BCL2)22Wehi/?	involves: 129 * C57BL	MGI:3776233
cx5	Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg} Tg(BCL2)22Wehi/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5445164
cx6	Cd79b^tm1Mnz/Cd79b^tm1Mnz Tg(BCL2)22Wehi/0 Tg(IghelMD4)4Ccg/0 Tg(Rag2-Igb)1Mnz/0	involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi	MGI:4453802
cx7	Cd79b^tm1Mnz/Cd79b^tm1Mnz Tg(BCL2)22Wehi/0 Tg(Rag2-Igb)1Mnz/0	involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi	MGI:4453801
cx8	Rad50^tm2Jpt/Rad50^tm2Jpt Tg(BCL2)22Wehi/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi	MGI:3615683
cx9	Tg(BCL2)22Wehi/0 Tg(IghMyc)22Bri/0	involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi	MGI:2662422
cx10	Fnip1^tm1.2Baba/Fnip1^tm1.2Baba Tg(BCL2)22Wehi/0	involves: C57BL/6 * FVB/N * SJL	MGI:5445170
cx11	Atp11c^m1Btlr/Y Tg(BCL2)22Wehi/0	involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi	MGI:5006847
cx12	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave Tg(BCL2)22Wehi/0	involves: C57BL/6JWehi * SJL/JWehi	MGI:5306147
cx13	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Tg(BCL2)22Wehi/0	involves: C57BL/6 * SJL	MGI:3687507
tg14	Tg(BCL2)22Wehi/0	involves: C57BL/6J * C57BL/6JWehi	MGI:3842940
tg15	Tg(BCL2)22Wehi/0	involves: C57BL/6JWehi * SJL/JWehi	MGI:3697915

Allelic Composition	Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺ Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Tg(BCL2)22Wehi/0
Genetic Background	involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^{tm3(cre/ERT2)Reth} mutation (3 available); any Cd79a mutation (29 available)
Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:208904 )

• severe after tamoxifen treatment

abnormal plasma cell differentiation ( J:208904 )

• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells

abnormal B cell physiology ( J:208904 )

• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment

enlarged lymph nodes ( J:208904 )

• severe after tamoxifen treatment

hematopoietic system

enlarged spleen ( J:208904 )

• severe after tamoxifen treatment

abnormal plasma cell differentiation ( J:208904 )

• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells

abnormal B cell physiology ( J:208904 )

• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment

growth/size/body

enlarged spleen ( J:208904 )

• severe after tamoxifen treatment

Allelic Composition	Cd79a^tm1(cre)Reth/Cd79a⁺ Dicer1^tm1Mmk/Dicer1^tm1Mmk Tg(BCL2)22Wehi/0
Genetic Background	involves: BALB/c * C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Dicer1^tm1Mmk mutation (0 available); any Dicer1 mutation (96 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:135783 )

• while B cell numbers are increased relative to in Cd79a^tm1(cre)Reth/Cd79a⁺ Dicer1^tm1Mmk/Dicer1^tm1Mmk mice, numbers are still lower than in wild-type mice

decreased mature B cell number ( J:135783 )

hematopoietic system

decreased B cell number ( J:135783 )

• while B cell numbers are increased relative to in Cd79a^tm1(cre)Reth/Cd79a⁺ Dicer1^tm1Mmk/Dicer1^tm1Mmk mice, numbers are still lower than in wild-type mice

decreased mature B cell number ( J:135783 )

Allelic Composition	Cd72^tm1Jrp/Cd72^tm1Jrp Tg(BCL2)22Wehi/0
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd72^tm1Jrp mutation (1 available); any Cd72 mutation (27 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased immature B cell number ( J:76990 )

• increase in the frequency of immature B cells in the spleen and bone marrow

decreased mature B cell number ( J:76990 )

• reduction in the frequency of mature B cells in the spleen and bone marrow

abnormal B cell physiology ( J:76990 )

• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells

hematopoietic system

increased immature B cell number ( J:76990 )

• increase in the frequency of immature B cells in the spleen and bone marrow

decreased mature B cell number ( J:76990 )

• reduction in the frequency of mature B cells in the spleen and bone marrow

abnormal B cell physiology ( J:76990 )

• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells

Allelic Composition	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(BCL2)22Wehi/?
Genetic Background	involves: 129 * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkrs^tm1Nemz mutation (1 available); any Igkrs mutation (1 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased anti-double stranded DNA antibody level ( J:132125 )

• there is a significant increase in IgG and IgM antibodies that bind DNA in the sera of 5 month old mice

Allelic Composition	Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg} Tg(BCL2)22Wehi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^{Gt(RRM154)Byg} mutation (0 available); any Fnip1 mutation (62 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

immune system

increased B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

Allelic Composition	Cd79b^tm1Mnz/Cd79b^tm1Mnz Tg(BCL2)22Wehi/0 Tg(IghelMD4)4Ccg/0 Tg(Rag2-Igb)1Mnz/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79b^tm1Mnz mutation (0 available); any Cd79b mutation (35 available)
Tg(BCL2)22Wehi mutation (3 available)
Tg(IghelMD4)4Ccg mutation (16 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested B cell differentiation ( J:78601 )

• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgM^low immature B cell stage is still impaired and no mature recirculating CD25^-IgM^high B cells are seen

immune system

arrested B cell differentiation ( J:78601 )

Allelic Composition	Cd79b^tm1Mnz/Cd79b^tm1Mnz Tg(BCL2)22Wehi/0 Tg(Rag2-Igb)1Mnz/0
Genetic Background	involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested B cell differentiation ( J:78601 )

• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired

immune system

arrested B cell differentiation ( J:78601 )

• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired

Allelic Composition	Rad50^tm2Jpt/Rad50^tm2Jpt Tg(BCL2)22Wehi/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• although mutants succumb to anemia, it is significantly later than in homozygous Rad50^tm2Jpt mice, with all dying by 7.5 months of age

hematopoietic system

anemia ( J:103922 )

• although mutants succumb to anemia, it is significantly later than in homozygous Rad50^tm2Jpt mice

Allelic Composition	Tg(BCL2)22Wehi/0 Tg(IghMyc)22Bri/0
Genetic Background	involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (3 available)
Tg(IghMyc)22Bri mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:69571 )

• animals become terminally ill at 5-6 weeks of age

neoplasm

increased lymphoma incidence ( J:69571 )

• masses of lymphoblasts occupy the spleen, lymph nodes and thymus and extensively invade the bone marrow, liver, lungs, and kidneys, an indication of malignant lymphoma

• tumors derive from a cell with the hallmarks of a primitive hematopoietic cell

hematopoietic system

enlarged thymus ( J:69571 )

enlarged spleen ( J:69571 )

increased leukocyte cell number ( J:69571 )

• 50- to 100-fold higher levels of white blood cells compared to controls

abnormal B cell morphology ( J:69571 )

• enlarged B cells

increased B cell number ( J:69571 )

• 70% increase in numbers of B cells in bone marrow and spleen

abnormal pre-B cell morphology ( J:69571 )

• enlarged pre-B cells

increased pre-B cell number ( J:69571 )

• 30% increase in numbers of pre-B cells in bone marrow and spleen

immune system

enlarged thymus ( J:69571 )

enlarged spleen ( J:69571 )

increased leukocyte cell number ( J:69571 )

• 50- to 100-fold higher levels of white blood cells compared to controls

abnormal B cell morphology ( J:69571 )

• enlarged B cells

increased B cell number ( J:69571 )

• 70% increase in numbers of B cells in bone marrow and spleen

abnormal pre-B cell morphology ( J:69571 )

• enlarged pre-B cells

increased pre-B cell number ( J:69571 )

• 30% increase in numbers of pre-B cells in bone marrow and spleen

enlarged lymph nodes ( J:69571 )

endocrine/exocrine glands

enlarged thymus ( J:69571 )

growth/size/body

enlarged spleen ( J:69571 )

Allelic Composition	Fnip1^tm1.2Baba/Fnip1^tm1.2Baba Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

immune system

increased B cell number ( J:189078 )

• in the bone marrow compared with Fnip1^tm1.2Tes or Fnip1^{Gt(RRM154)Byg} homozygotes

Allelic Composition	Atp11c^m1Btlr/Y Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11c^m1Btlr mutation (1 available); any Atp11c mutation (14 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased marginal zone B cell number ( J:171925 )

• compared to in Tg(BCL2)22Wehi mice or Atp11c^m1Btlr hemizygotes

decreased B cell number ( J:171925 )

• the percentage of CD19+ B cells is partially rescued compared to in Atp11c^m1Btlr hemizygotes

decreased mature B cell number ( J:171925 )

• as in Atp11c^m1Btlr hemizygotes in the bone marrow

decreased follicular B cell number ( J:171925 )

• follicular B cell numbers are partially rescued compared to in Atp11c^m1Btlr hemizygotes

hematopoietic system

increased marginal zone B cell number ( J:171925 )

• compared to in Tg(BCL2)22Wehi mice or Atp11c^m1Btlr hemizygotes

decreased B cell number ( J:171925 )

• the percentage of CD19+ B cells is partially rescued compared to in Atp11c^m1Btlr hemizygotes

decreased mature B cell number ( J:171925 )

• as in Atp11c^m1Btlr hemizygotes in the bone marrow

decreased follicular B cell number ( J:171925 )

• follicular B cell numbers are partially rescued compared to in Atp11c^m1Btlr hemizygotes

Allelic Composition	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1.1Lave mutation (0 available); any Igh-J mutation (12 available)
Igk-J^tm1.1Lave mutation (0 available); any Igk-J mutation (9 available)
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:179317 )

• B cell development is partially rescued

hematopoietic system

abnormal B cell differentiation ( J:179317 )

• B cell development is partially rescued

Allelic Composition	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (3 available)
Tnfrsf13c^tm1Mass mutation (1 available); any Tnfrsf13c mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:113365 )

immune system

immune system phenotype ( J:92732 )

N	• B cell development is normal in these mutants unlike Tnfrsf13c^tm1Mass homozygotes

Allelic Composition	Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6J * C57BL/6JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell number ( J:88565 )

immune system

increased B cell number ( J:88565 )

Allelic Composition	Tg(BCL2)22Wehi/0
Genetic Background	involves: C57BL/6JWehi * SJL/JWehi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:93111 )

• most transgenic B cells are smaller than normal B cells

increased B cell number ( J:93111 )

• mutants show a 2- to 5-fold excess of B lymphocytes in spleen, lymph nodes, and bone marrow

abnormal B cell physiology ( J:93111 )

• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes

immune system

abnormal B cell differentiation ( J:93111 )

• most transgenic B cells are smaller than normal B cells

increased B cell number ( J:93111 )

• mutants show a 2- to 5-fold excess of B lymphocytes in spleen, lymph nodes, and bone marrow

abnormal B cell physiology ( J:93111 )

• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes

increased susceptibility to autoimmune disorder ( J:93111 )

• a portion of transgenic mice develop autoimmune-like disease

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