Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3(cre/ERT2)Reth mutation
(2 available);
any
Cd79a mutation
(22 available)
Gt(ROSA)26Sortm1(ETV6/SYK)Hjum mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• severe after tamoxifen treatment
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• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
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• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment
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• severe after tamoxifen treatment
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hematopoietic system
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• severe after tamoxifen treatment
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• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
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• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment
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growth/size/body
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• severe after tamoxifen treatment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Dicer1tm1Mmk mutation
(0 available);
any
Dicer1 mutation
(94 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice
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hematopoietic system
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• while B cell numbers are increased relative to in Cd79atm1(cre)Reth/Cd79a+ Dicer1tm1Mmk/Dicer1tm1Mmk mice, numbers are still lower than in wild-type mice
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Allelic
Composition |
Cd72tm1Jrp/Cd72tm1Jrp
Tg(BCL2)22Wehi/0
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Genetic
Background |
either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd72tm1Jrp mutation
(1 available);
any
Cd72 mutation
(29 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• increase in the frequency of immature B cells in the spleen and bone marrow
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• reduction in the frequency of mature B cells in the spleen and bone marrow
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• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells
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hematopoietic system
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• increase in the frequency of immature B cells in the spleen and bone marrow
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• reduction in the frequency of mature B cells in the spleen and bone marrow
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• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkrstm1Nemz mutation
(1 available);
any
Igkrs mutation
(1 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• there is a significant increase in IgG and IgM antibodies that bind DNA in the sera of 5 month old mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1Gt(RRM154)Byg mutation
(0 available);
any
Fnip1 mutation
(59 available)
Tg(BCL2)22Wehi mutation
(2 available)
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hematopoietic system
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• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
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immune system
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• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation
(0 available);
any
Cd79b mutation
(36 available)
Tg(BCL2)22Wehi mutation
(2 available)
Tg(IghelMD4)4Ccg mutation
(3 available)
Tg(Rag2-Igb)1Mnz mutation
(0 available)
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hematopoietic system
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• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgMlow immature B cell stage is still impaired and no mature recirculating CD25-IgMhigh B cells are seen
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immune system
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• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgMlow immature B cell stage is still impaired and no mature recirculating CD25-IgMhigh B cells are seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation
(0 available);
any
Cd79b mutation
(36 available)
Tg(BCL2)22Wehi mutation
(2 available)
Tg(Rag2-Igb)1Mnz mutation
(0 available)
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hematopoietic system
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• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired
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immune system
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• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation
(0 available);
any
Rad50 mutation
(53 available)
Tg(BCL2)22Wehi mutation
(2 available)
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mortality/aging
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• although mutants succumb to anemia, it is significantly later than in homozygous Rad50tm2Jpt mice, with all dying by 7.5 months of age
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hematopoietic system
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• although mutants succumb to anemia, it is significantly later than in homozygous Rad50tm2Jpt mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation
(2 available)
Tg(IghMyc)22Bri mutation
(1 available)
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mortality/aging
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• animals become terminally ill at 5-6 weeks of age
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neoplasm
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• masses of lymphoblasts occupy the spleen, lymph nodes and thymus and extensively invade the bone marrow, liver, lungs, and kidneys, an indication of malignant lymphoma
• tumors derive from a cell with the hallmarks of a primitive hematopoietic cell
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hematopoietic system
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• 50- to 100-fold higher levels of white blood cells compared to controls
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• 70% increase in numbers of B cells in bone marrow and spleen
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• 30% increase in numbers of pre-B cells in bone marrow and spleen
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immune system
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• 50- to 100-fold higher levels of white blood cells compared to controls
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• 70% increase in numbers of B cells in bone marrow and spleen
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• 30% increase in numbers of pre-B cells in bone marrow and spleen
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endocrine/exocrine glands
growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
Tg(BCL2)22Wehi mutation
(2 available)
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hematopoietic system
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• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
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immune system
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• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation
(1 available);
any
Atp11c mutation
(16 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
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• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
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• as in Atp11cm1Btlr hemizygotes in the bone marrow
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• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes
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hematopoietic system
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• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
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• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
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• as in Atp11cm1Btlr hemizygotes in the bone marrow
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• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1.1Lave mutation
(0 available);
any
Igh-J mutation
(13 available)
Igk-Jtm1.1Lave mutation
(0 available);
any
Igk-J mutation
(11 available)
Tg(BCL2)22Wehi mutation
(2 available)
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immune system
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• B cell development is partially rescued
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hematopoietic system
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• B cell development is partially rescued
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation
(2 available)
Tnfrsf13ctm1Mass mutation
(1 available);
any
Tnfrsf13c mutation
(14 available)
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homeostasis/metabolism
immune system
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N |
• B cell development is normal in these mutants unlike Tnfrsf13ctm1Mass homozygotes
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Allelic
Composition |
Tg(BCL2)22Wehi/0
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Genetic
Background |
involves: C57BL/6J * C57BL/6JWehi |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation
(2 available)
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hematopoietic system
immune system
Allelic
Composition |
Tg(BCL2)22Wehi/0
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Genetic
Background |
involves: C57BL/6JWehi * SJL/JWehi |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation
(2 available)
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hematopoietic system
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• most transgenic B cells are smaller than normal B cells
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• mutants show a 2- to 5-fold excess of B lymphocytes in spleen, lymph nodes, and bone marrow
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• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
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immune system
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• most transgenic B cells are smaller than normal B cells
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• mutants show a 2- to 5-fold excess of B lymphocytes in spleen, lymph nodes, and bone marrow
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• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes
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• a portion of transgenic mice develop autoimmune-like disease
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Analysis Tools