Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hassan Jumaa
• MGI ID: MGI:5568502
• Synonyms: TEL-SYK, TS
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208904
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ETV6 (2120)

  Etv6	(MGI:109336)

  human

  SYK (6850)

  Syk	(MGI:99515)

• Mutation details: The targeting vector introduced into the locus a splice acceptor, loxP site, RFP, FRT-flanked neomycin resistance cassette, polyadenylation STOP sequence, loxP site and fusion of human ETV6 and SYK. The fusion product in a constitutively active form of Syk identified in human patients with myelodysplastic syndrome. (J:208904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:208904 Hug E, et al., Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation. Oncogene. 2014 Jul 10;33(28):3730-41
• All: 1 reference(s)