All Phenotypes Tcra<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcra⁺
wild type
MGI:3049848

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tcra^Ln3Jae/Tcra⁺	B6.Cg-Tcra^Ln3Jae	MGI:3834658
ht2	Tcra^Ln1Ogu/Tcra⁺	involves: 129/Sv * C57BL/6	MGI:4356164
ht3	Tcra^tm1Mjo/Tcra⁺	NOD.129P2-Tcra^tm1Mjo	MGI:4944217
ht4	Tcra^tm1Mjo/Tcra⁺	SJL.129P2-Tcra^tm1Mjo	MGI:4944219
cn5	Tcra^tm1Mass/Tcra⁺ Tg(Nes-cre)Wme/0	involves: C57BL/6 * CBA	MGI:5532668
cn6	Tcra^tm1Mass/Tcra⁺ Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:5532666
cx7	Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺	B6.Cg-Tcrb^Ln3Jae Tcra^Ln3Jae	MGI:3834654
cx8	Tcra^Ln1Ogu/Tcra⁺ Tcrb^Ln1Ogu/Tcrb⁺	involves: 129/Sv * C57BL/6	MGI:4356144
cx9	Tcra^Ln2Ogu/Tcra⁺ Tcrb^Ln2Ogu/Tcrb⁺	involves: 129/Sv * C57BL/6	MGI:4356145
cx10	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tcra^Ln1Ogu/Tcra⁺	involves: 129/Sv * C57BL/6	MGI:4356165
cx11	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^b/H2^b Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807222
cx12	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807288
cx13	Rag2^tm1Fwa/Rag2^tm1Fwa Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:3834655
cx14	Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra⁺	MRL.Cg-Tcra^tm1Mjo Fas^lpr	MGI:4944218

Allelic Composition	Tcra^Ln3Jae/Tcra⁺
Genetic Background	B6.Cg-Tcra^Ln3Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by more than 5-fold

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is found abundantly in the spleen making up 31% of the splenocyte population

decreased double-positive T cell number ( J:143006 )

• there is about a 2-fold reduction in the percentage of double-positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 2-fold increase in the percentage of CD8⁺ single positive thymocytes

hematopoietic system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by more than 5-fold

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is found abundantly in the spleen making up 31% of the splenocyte population

decreased double-positive T cell number ( J:143006 )

• there is about a 2-fold reduction in the percentage of double-positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 2-fold increase in the percentage of CD8⁺ single positive thymocytes

endocrine/exocrine glands

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by more than 5-fold

Allelic Composition	Tcra^Ln1Ogu/Tcra⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln1Ogu mutation (0 available); any Tcra mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:152041 )

• there are almost 10-fold lower thymocytes compared to controls

abnormal T cell subpopulation ratio ( J:152041 )

• the percentage of single-positive thymocytes is increased

• the percentage of double-positive thymocytes is decreased compared to controls

abnormal NK T cell morphology ( J:152041 )

• some CD8-single positive NKT cells are found in the liver

• iNKT T cells have a bias towards expressing a receptor encoded in part by the TCRVbeta8 gene segment

increased NK T cell number ( J:152041 )

decreased splenocyte number ( J:152041 )

• splenocyte numbers are almost cut in half

increased IgG1 level ( J:152041 )

• IgG1 levels are increased about 5-fold

decreased IgG2a level ( J:152041 )

• IgG2a levels are decreased about 10-fold

abnormal cytokine secretion ( J:152041 )

• GM-CSF levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection

increased interferon-gamma secretion ( J:152041 )

• IFN-gamma levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection

• increased IFN-gamma levels result from increased numbers of iNKT cells

increased interleukin-10 secretion ( J:152041 )

• IL-10 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection

increased interleukin-2 secretion ( J:152041 )

• IL-2 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection

increased interleukin-4 secretion ( J:152041 )

• IL-4 levels are more than 10-fold higher than controls 4 hours after alphaGalCer injection

• increased IL-4 levels result from increased numbers of iNKT cells

liver/biliary system

abnormal liver morphology ( J:152041 )

• the number of lymphocytes in the liver is more than double of controls

hematopoietic system

decreased thymocyte number ( J:152041 )

• there are almost 10-fold lower thymocytes compared to controls

abnormal T cell subpopulation ratio ( J:152041 )

• the percentage of single-positive thymocytes is increased

• the percentage of double-positive thymocytes is decreased compared to controls

abnormal NK T cell morphology ( J:152041 )

• some CD8-single positive NKT cells are found in the liver

• iNKT T cells have a bias towards expressing a receptor encoded in part by the TCRVbeta8 gene segment

increased NK T cell number ( J:152041 )

decreased splenocyte number ( J:152041 )

• splenocyte numbers are almost cut in half

increased IgG1 level ( J:152041 )

• IgG1 levels are increased about 5-fold

decreased IgG2a level ( J:152041 )

• IgG2a levels are decreased about 10-fold

endocrine/exocrine glands

decreased thymocyte number ( J:152041 )

• there are almost 10-fold lower thymocytes compared to controls

Allelic Composition	Tcra^tm1Mjo/Tcra⁺
Genetic Background	NOD.129P2-Tcra^tm1Mjo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mjo mutation (7 available); any Tcra mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:108590 )

• unlike in wild-type controls no dual TCRA expressing cells are present

decreased susceptibility to autoimmune diabetes ( J:108590 )

• males and females are significantly protected from cyclophosphamide induced diabetes compared to wild-type controls

• marker analysis confirms that multiple susceptibility loci are entirely NOD derived

hematopoietic system

abnormal T cell physiology ( J:108590 )

• unlike in wild-type controls no dual TCRA expressing cells are present

Allelic Composition	Tcra^tm1Mjo/Tcra⁺
Genetic Background	SJL.129P2-Tcra^tm1Mjo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mjo mutation (7 available); any Tcra mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:108590 )

N	• no difference in the susceptibility to experimental autoimmune encephalomyelitis is detected compared to wild-type controls

Allelic Composition	Tcra^tm1Mass/Tcra⁺ Tg(Nes-cre)Wme/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mass mutation (0 available); any Tcra mutation (102 available)
Tg(Nes-cre)Wme mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:201417 )

abnormal positive T cell selection ( J:201417 )

• perturbed

increased double-negative T cell number ( J:201417 )

decreased NK T cell number ( J:201417 )

• in the thymus and spleen

hematopoietic system

decreased thymocyte number ( J:201417 )

abnormal positive T cell selection ( J:201417 )

• perturbed

increased double-negative T cell number ( J:201417 )

decreased NK T cell number ( J:201417 )

• in the thymus and spleen

endocrine/exocrine glands

decreased thymocyte number ( J:201417 )

Allelic Composition	Tcra^tm1Mass/Tcra⁺ Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mass mutation (0 available); any Tcra mutation (102 available)
Tg(Cd4-cre)1Cwi mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK cell number ( J:201417 )

abnormal NK T cell morphology ( J:201417 )

• abnormal NK T cell maturation

increased NK T cell number ( J:201417 )

• 23 times more in the thymus

• 43 times more in the spleen

• in mice treated with galactosylceramide

hematopoietic system

decreased NK cell number ( J:201417 )

abnormal NK T cell morphology ( J:201417 )

• abnormal NK T cell maturation

increased NK T cell number ( J:201417 )

• 23 times more in the thymus

• 43 times more in the spleen

• in mice treated with galactosylceramide

Allelic Composition	Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	B6.Cg-Tcrb^Ln3Jae Tcra^Ln3Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

abnormal T cell differentiation ( J:143006 )

• the pre-arranged TCR genes are expressed abnormally early with intracellular TCR-beta chains detectable in the 75% of the common lymphoid progenitors in the bone marrow

• these TCR-beta chains were also detectable in 35% of multipotent progenitors, 12% of short-term hemopoietic stem cells, and 5% of long-term hemopoietic stem cells of the bone marrow

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is rarely found in the spleen

decreased double-positive T cell number ( J:143006 )

• there is a greater than 4-fold reduction in the percentage of double-positive thymocytes

• the double-positive thymus makes up 83% of the normal thymus but only 16% in these mutants

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 10-fold increase in the percentage of CD8⁺ single positive thymocytes

• the percentage of CD8⁺ T cells among splenocytes is more than double that of controls

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

hematopoietic system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

abnormal T cell differentiation ( J:143006 )

• the pre-arranged TCR genes are expressed abnormally early with intracellular TCR-beta chains detectable in the 75% of the common lymphoid progenitors in the bone marrow

• these TCR-beta chains were also detectable in 35% of multipotent progenitors, 12% of short-term hemopoietic stem cells, and 5% of long-term hemopoietic stem cells of the bone marrow

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is rarely found in the spleen

decreased double-positive T cell number ( J:143006 )

• there is a greater than 4-fold reduction in the percentage of double-positive thymocytes

• the double-positive thymus makes up 83% of the normal thymus but only 16% in these mutants

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 10-fold increase in the percentage of CD8⁺ single positive thymocytes

• the percentage of CD8⁺ T cells among splenocytes is more than double that of controls

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

endocrine/exocrine glands

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

Allelic Composition	Tcra^Ln1Ogu/Tcra⁺ Tcrb^Ln1Ogu/Tcrb⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln1Ogu mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln1Ogu mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:152069 )

• mice are heavier than controls

immune system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

hematopoietic system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

Allelic Composition	Tcra^Ln2Ogu/Tcra⁺ Tcrb^Ln2Ogu/Tcrb⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln2Ogu mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln2Ogu mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:152069 )

• mice are heavier than controls

immune system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

hematopoietic system

abnormal T cell morphology ( J:152069 )

• all T cell express the Vbeta8 gene segment compared to just 20% in controls

Allelic Composition	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tcra^Ln1Ogu/Tcra⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
Tcra^Ln1Ogu mutation (0 available); any Tcra mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell morphology ( J:152041 )

• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers

• immature iNKT cells that are CD24⁺CD44^dullNK1.1^- are very abundant in the thymus

hematopoietic system

abnormal NK T cell morphology ( J:152041 )

• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers

• immature iNKT cells that are CD24⁺CD44^dullNK1.1^- are very abundant in the thymus

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^b/H2^b Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (34 available); any H2 mutation (304 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (16 available)
Tcra^tm1Mom mutation (8 available); any Tcra mutation (102 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

immune system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (24 available); any H2 mutation (304 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (12 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (16 available)
Tcra^tm1Mom mutation (8 available); any Tcra mutation (102 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (46 available); any Rag2 mutation (121 available)
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (102 available)
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up less than 1% of the splenocyte population

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• 99% of T cells in the spleen are CD8⁺ T cells

• 46% of thymocytes are single-positive CD8⁺ cells

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

hematopoietic system

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up less than 1% of the splenocyte population

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• 99% of T cells in the spleen are CD8⁺ T cells

• 46% of thymocytes are single-positive CD8⁺ cells

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

Allelic Composition	Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra⁺
Genetic Background	MRL.Cg-Tcra^tm1Mjo Fas^lpr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (82 available)
Tcra^tm1Mjo mutation (7 available); any Tcra mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:108590 )

N	• no difference in the susceptibility to systemic lupus erythematosus is detected compared to wild-type controls

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