Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1.1(Ascl1)Nlbr mutation
(0 available);
any
Atoh7 mutation
(9 available)
Tg(Atoh7-cre)360Gla mutation
(0 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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vision/eye
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• delayed retinal ganglion cell differentiation
• however, adult mice exhibit normal proportion of retinal ganglion cells
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nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7tm1.1(Ascl1)Nlbr mutation
(0 available);
any
Atoh7 mutation
(9 available)
Tg(Atoh7-cre)360Gla mutation
(0 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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vision/eye
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• increased retinal apoptosis at E12.5 to E16.5
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• cell autonomous phenotype
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• cell nonautonomous phenotype
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• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression and retinal ganglion cell differentiation
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nervous system
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• cell autonomous phenotype
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• cell nonautonomous phenotype
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cellular
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• at E12.5 and E13.5, retinal progenitor cells exhibit a block to cell cycle progression
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• increased retinal apoptosis at E12.5 to E16.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Hap mutation
(0 available);
any
Itga3 mutation
(52 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(SFTPC-rtTA)5Jaw mutation
(4 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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respiratory system
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• epithelial to mesenchymal transition results from bleomycin-mediated injury of the lung
• only 1.4% of GFP+, epithelium derived cells express mesenchyme markers 17 days after bleomycin injury compared to 7.0% in controls
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nervous system
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• olfactory sensory neurons expressing the null allele of Nrp1 have an altered and variable pattern of glomeruli formation in the olfactory bulb, including ectopic glomeruli, but the labeled glomeruli do not show an anterior shift relative to Nrp1 wild type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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nervous system
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• subventricular neural stem cells treated in culture with adenoviral cre exhibit decreased differentiation compared to wild-type cells
• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 2-fold more oligodendrocytes and 50% more astrocytes than similarly treated wild-type cells
• however, proliferation and apoptosis rates are normal
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• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 3-fold fewer Tuj1+ (marking neuron precursor cells) compared similarly treated wild-type cells
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cellular
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• subventricular neural stem cells treated in culture with adenoviral cre exhibit decreased differentiation compared to wild-type cells
• under differentiation condition, cultured subventricular zone cells treated with adenovirus cre produce 2-fold more oligodendrocytes and 50% more astrocytes than similarly treated wild-type cells
• however, proliferation and apoptosis rates are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(Pmch-cre)1Lowl mutation
(2 available)
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homeostasis/metabolism
nervous system
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• only about 14% of Pmch neurons show spontaneous action potentials at 5 mM glucose in brain slice preparations compared to 30% of neurons in wild-type preparations, indicating disrupted glucose-sensing
• membrane resistance of Pmch neurons is significantly reduced relative to wild-type neurons at 5 mM glucose
• almost all neurons do not hyperpolarize when extracellular glucose is reduced from 5 to 1 mM whereas around 70% of control neurons hyperpolarize under these conditions, indicating disrupted glucose-sensing
• glucose-induced depolarization is abrogated in Pmch neurons, but is readily observed in control Pmch neurons, indicating disrupted glucose-sensing
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homeostasis/metabolism
nervous system
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• about 44% of Pmch neurons fire spontaneously at 5 mM glucose, increased from around 30% of control neurons
• membrane potential of Pmch neurons displays enhanced glucose-induced depolarization in response to different glucose concentrations (left-shifted dose-response curve to glucose)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Barhl2tm1Gan mutation
(0 available);
any
Barhl2 mutation
(15 available)
Barhl2tm2(cre)Gan mutation
(0 available);
any
Barhl2 mutation
(15 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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vision/eye
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• loss of 95% of Barhl2 lineage cells
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nervous system
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• loss of 95% of Barhl2 lineage cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a6tm1Lowl mutation
(2 available);
any
Slc17a6 mutation
(59 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(Nr5a1-cre)2Lowl mutation
(1 available)
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adipose tissue
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• when fed a high fat diet, mice exhibit a slight increase in fat stores
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behavior/neurological
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• when fed a high fat diet, mice exhibit a slight increase in food intake
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growth/size/body
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• when fed a high fat diet, mice exhibit a slight increase in fat stores
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• mice exhibit a greater increase in weight when fed a high fat diet compared to wild-type mice
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homeostasis/metabolism
nervous system
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• neurons do not possess any glutamatergic excitatory postsynaptic current
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm1Meg mutation
(0 available);
any
Bhlhe22 mutation
(12 available)
Bhlhe22tm3.1(cre)Meg mutation
(0 available);
any
Bhlhe22 mutation
(12 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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nervous system
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• in the superficial laminae of spinal cord, there are significantly fewer lacZ-marked neurons compared to controls; significant loss of cell bodies and neuropil is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3tm1.2Good mutation
(0 available);
any
Fat3 mutation
(240 available)
Ptf1atm1.1(cre)Cvw mutation
(1 available);
any
Ptf1a mutation
(30 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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nervous system
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• amacrine cells retain two processes after reaching the inner plexiform layer unlike unipolar wild-type cells
• amacrine cells fail to retract trailing processes upon reaching the inner plexiform layer
• amacrine cells develop a second arbor that extends to the outer misplaced plexiform layer
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vision/eye
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• amacrine cells retain two processes after reaching the inner plexiform layer unlike unipolar wild-type cells
• amacrine cells fail to retract trailing processes upon reaching the inner plexiform layer
• amacrine cells develop a second arbor that extends to the outer misplaced plexiform layer
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• amacrine cells form two additional plexiform layers (inner and outer misplaced plexiform layers) compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fscn1Gt(OST124903)Lex mutation
(1 available);
any
Fscn1 mutation
(42 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(Tyr-cre)1Lru mutation
(1 available)
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embryo
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• melanoblasts in E14.5 skin explants show significantly reduced cell migration speed and euclidean distance travelled relative to wild-type controls
• ~30% of melanoblasts migrate with a speed slower than 0.5 um/minute versus fewer than 10% of melanoblasts in wild-type explants
• however, directionality (the ratio between the euclidean distance and total distance travelled) is normal
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• melanoblasts in E14.5 live skin explants are slightly smaller than wild type
• the rate of pseudopod generation in melanoblasts is modestly reduced but the lifetime of pseudopods is increased
• melanoblasts extend thinner protrusions with a smaller cross-sectional width than wild type controls
• thinner pseudopodia are less dynamic (longer-lived) leading to slower melanoblast migration
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cellular
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• melanoblasts in E14.5 skin explants show significantly reduced cell migration speed and euclidean distance travelled relative to wild-type controls
• ~30% of melanoblasts migrate with a speed slower than 0.5 um/minute versus fewer than 10% of melanoblasts in wild-type explants
• however, directionality (the ratio between the euclidean distance and total distance travelled) is normal
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nervous system
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• melanoblasts in E14.5 live skin explants are slightly smaller than wild type
• the rate of pseudopod generation in melanoblasts is modestly reduced but the lifetime of pseudopods is increased
• melanoblasts extend thinner protrusions with a smaller cross-sectional width than wild type controls
• thinner pseudopodia are less dynamic (longer-lived) leading to slower melanoblast migration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd4tm1.1Kge mutation
(0 available);
any
Chd4 mutation
(58 available)
Chd4tm1.2Kge mutation
(0 available);
any
Chd4 mutation
(58 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(Lck-cre)1Cwi mutation
(3 available)
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cellular
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• progressive decrease in cycling T cells is observed from second to third cell division in vitro, along with large number of nonblast T cells that appear to fail to enter cell cycle
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• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase
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immune system
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• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase
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hematopoietic system
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• a 5- to 7-fold decrease in proliferation is observed relative to wild-type cells in vitro after 48 hours of TCR/CD3 stimulation; fewer mutant cells are in S phase
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camkk2tm2.1Kpg mutation
(0 available);
any
Camkk2 mutation
(40 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(Pomc1-cre)1Gsb mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm1Gan mutation
(0 available);
any
Bhlhe22 mutation
(12 available)
Bhlhe22tm2(cre)Gan mutation
(0 available);
any
Bhlhe22 mutation
(12 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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nervous system
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• at P0, no Bhlhe22-expression fibers are detected in the medullary pyramidal tract unlike in wild-type mice
• in adults, few Bhlhe22-expression fibers are detected in the medullary pyramidal tract unlike in wild-type mice
• Bhlhe22-expression fibers present in the decussation do not enter the ventral dorsal funiculus of the spinal cord unlike in wild-type mice
• fewer than normal subcerebral projection neurons enter the medullary pyramidal tract while caudal corticospinal motor neurons fail to enter the tract
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2tm1.1(cre)Oki mutation
(0 available);
any
Shox2 mutation
(19 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Vsx2tm1(DTA)Kash mutation
(0 available);
any
Vsx2 mutation
(23 available)
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nervous system
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• number of Shox2-expressing V2a interneurons is reduced by 98%; total number of Shox2-expressing interneurons is reduced by >80%
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• variability in locomotor parameters (cycle period, burst duration, amplitude) that are observed in isolated neonatal spinal cords exposed to low NMDA concentrations is increased in mutants compared to controls; higher NMDA concentrations reduce this variability
• other parameters such as burst frequency and flexor-extensor alternation are not significantly different
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm2Kln mutation
(0 available);
any
Ntrk2 mutation
(66 available)
Slc1a3tm1(cre/ERT2)Mgoe mutation
(0 available);
any
Slc1a3 mutation
(66 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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nervous system
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• synaptic contacts appear to be normal for neurons arising in hippocampus from radial glial cells after treatment with tamoxifen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1tm1.1Msan mutation
(1 available);
any
Nkx6-1 mutation
(4 available)
Nkx6-1tm1Jlr mutation
(0 available);
any
Nkx6-1 mutation
(4 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Tg(Neurog3-cre)C1Able mutation
(2 available)
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mortality/aging
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• mice die within the first few days after birth
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endocrine/exocrine glands
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N |
• mice do not exhibit endocrine-to-acinar fate conversion
• beta cells exhibit normal cell proliferation and apoptosis
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• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells
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• due to reduced differentiation without an effect on proliferation and apoptosis
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homeostasis/metabolism
cellular
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• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1.1Mfre mutation
(0 available);
any
Cacnb2 mutation
(50 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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mortality/aging
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• mice die following E10.5 and are completely absorbed by E11.5
• however, treatment with a calcium channel agonist, 1 umol/L (-)-BayK 8644, partially rescues embryonic lethality with mice surviving until the end of E11.5
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cardiovascular system
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• at E10.5, a stenosis is frequently observed between the emerging right ventricle and the outflow tract
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• at E10.5, mice display abnormal heart looping
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• at E10.5, mice display abnormal heart looping with amorphous heart tubes lying distorted within the pericardial cavity, and a stenosis is frequently observed between the emerging right ventricle and the outflow tract
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• at E10.5, pericardial effusion is associated with hemorrhages
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• at E10.5, hearts only exhibit barely noticeable tremors without any noticeable ejection volume
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• at E10.5, pericardial effusion is associated with hemorrhages
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• 63+/-2.88 beats per minute compared to 120+/-3.15 beats per minute in wild-type mice
• however, no difference in heart rate is observed at E9.5
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• at E10.5, L-type calcium channel activity and calcium-induced calcium release is impaired resulting in diminished heart pumping
• calcium channel current density is reduced compared to in wild-type mice
• unlike wild-type cardiomyocytes, E9.5 cardiomyocytes fail to respond to catecholamine treatment
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embryo
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• unlike in wild-type mice, embryos size does not double between E9.5 and E10.5
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• at E9.5, vascular remodeling of the primary capillary plexus fails to occur and a honeycomb-like network of tubules with enlarged and uniform diameters forms in the extra- and intraembryonic vasculature
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nervous system
growth/size/body
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• between E9.5 and E10.5, mice exhibit poor growth of facial primordial tissue
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• unlike in wild-type mice, embryos size does not double between E9.5 and E10.5
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craniofacial
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• between E9.5 and E10.5, mice exhibit poor growth of facial primordial tissue
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homeostasis/metabolism
hematopoietic system
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• very few hemangioblasts are found in the blood vessels of the yolk sac
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muscle
Analysis Tools