Camkk2^tm2.1Kpg
Targeted Allele Detail

Summary

• Symbol: Camkk2^tm2.1Kpg
• Name: calcium/calmodulin-dependent protein kinase kinase 2, beta; targeted mutation 2.1, K Peter Giese
• MGI ID: MGI:4946512
• Gene: Camkk2 Location: Chr5:122869233-122917472 bp, - strand Genetic Position: Chr5, 62.55 cM
• Alliance: Camkk2^tm2.1Kpg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170130
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. A floxed neo cassette was inserted downstream of exon 5. Cre-mediated recombination removed the neo cassette leaving exon 5 floxed. (J:170130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camkk2 Mutation: 40 strains or lines available

References

• Original: J:170130 Claret M, et al., Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes. 2011 Mar;60(3):735-45
• All: 1 reference(s)