All Phenotypes Hoxa3<tm1(cre)Moon> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmp4^tm4Blh/Bmp4⁺ Bmp7^tm1.1Dgra/Bmp7^tm1.1Dgra Hoxa3^tm1(cre)Moon/Hoxa3⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5642274
cn2	Hoxa3^tm1(cre)Moon/Hoxa3⁺ Tbx1^tm3Bld/Tbx1^tm1Bld	involves: 129S7/SvEvBrd * C57BL/6	MGI:3641322
cn3	Fgf8^tm1Mrc/Fgf8^tm2Mrc Hoxa3^tm1(cre)Moon/Hoxa3⁺	involves: 129/Sv * C57BL/6	MGI:2686876
cn4	Fgf8^tm1Mrc/Fgf8^tm1Moon Hoxa3^tm1(cre)Moon/Hoxa3⁺	involves: 129/Sv * C57BL/6	MGI:2686877
cn5	Pdgfra^tm8Sor/Pdgfra^tm8Sor Hoxa3^tm1(cre)Moon/Hoxa3⁺	Not Specified	MGI:7545278

Allelic Composition	Bmp4^tm4Blh/Bmp4⁺ Bmp7^tm1.1Dgra/Bmp7^tm1.1Dgra Hoxa3^tm1(cre)Moon/Hoxa3⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm4Blh mutation (0 available); any Bmp4 mutation (21 available)
Bmp7^tm1.1Dgra mutation (0 available); any Bmp7 mutation (37 available)
Hoxa3^tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

anal stenosis ( J:192045 )

embryo

sirenomelia ( J:192045 )

• hindlimb fusion

limbs/digits/tail

sirenomelia ( J:192045 )

• hindlimb fusion

renal/urinary system

absent urinary bladder ( J:192045 )

Allelic Composition	Hoxa3^tm1(cre)Moon/Hoxa3⁺ Tbx1^tm3Bld/Tbx1^tm1Bld
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm3Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:110620 )

• at E18.5 embryos are found to display PTA

Allelic Composition	Fgf8^tm1Mrc/Fgf8^tm2Mrc Hoxa3^tm1(cre)Moon/Hoxa3⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8^tm1Mrc mutation (0 available); any Fgf8 mutation (18 available)
Fgf8^tm2Mrc mutation (0 available); any Fgf8 mutation (18 available)
Hoxa3^tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:87304 )

• 30% die during the neonatal period because of lethal cardiovascular malformations

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:87304 )

• pharyngeal arch artery defects

abnormal fourth pharyngeal arch artery morphology ( J:87304 )

• defect in vascular tube formation in the fourth pharyngeal arch

enlarged third pharyngeal arch artery ( J:87304 )

• exhibit an abnormally large third pharyngeal arch artery

abnormal truncus arteriosus septation ( J:87304 )

• only 1 of 33 have severe perturbation of outflow tract septation and alignment (Tetralogy of Fallot and BAV)

abnormal coronary vessel morphology ( J:87304 )

• coronary vascular defects

bicuspid aortic valve ( J:87304 )

• 23% exhibit bicuspid aortic valves

hematopoietic system

thymus hypoplasia ( J:87304 )

• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

ectopic thymus ( J:87304 )

endocrine/exocrine glands

abnormal parathyroid gland morphology ( J:87304 )

• parathyroid ectopy, hypoplasia, and aplasia

absent parathyroid glands ( J:87304 )

• parathyroid gland aplasia

ectopic parathyroid gland ( J:87304 )

parathyroid hypoplasia ( J:87304 )

thymus hypoplasia ( J:87304 )

• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

ectopic thymus ( J:87304 )

immune system

thymus hypoplasia ( J:87304 )

• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

ectopic thymus ( J:87304 )

craniofacial

abnormal pharyngeal arch artery morphology ( J:87304 )

• pharyngeal arch artery defects

abnormal fourth pharyngeal arch artery morphology ( J:87304 )

• defect in vascular tube formation in the fourth pharyngeal arch

enlarged third pharyngeal arch artery ( J:87304 )

• exhibit an abnormally large third pharyngeal arch artery

embryo

abnormal pharyngeal arch artery morphology ( J:87304 )

• pharyngeal arch artery defects

abnormal fourth pharyngeal arch artery morphology ( J:87304 )

• defect in vascular tube formation in the fourth pharyngeal arch

enlarged third pharyngeal arch artery ( J:87304 )

• exhibit an abnormally large third pharyngeal arch artery

abnormal neural crest cell apoptosis ( J:87304 )

• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8

cellular

abnormal neural crest cell apoptosis ( J:87304 )

• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:87304 )

• 30% die during the neonatal period because of lethal cardiovascular malformations

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:87304 )

• exhibit pharyngeal arch artery defects

abnormal fourth pharyngeal arch artery morphology ( J:87304 )

• defect in vascular tube formation in the fourth pharyngeal arch

enlarged third pharyngeal arch artery ( J:87304 )

• exhibit an abnormally large third pharyngeal arch artery

abnormal truncus arteriosus septation ( J:87304 )

• only 1 of 33 have severe perturbation of outflow tract septation and alignment (Tetralogy of Fallot and BAV)

abnormal coronary vessel morphology ( J:87304 )

• coronary vascular defects

bicuspid aortic valve ( J:87304 )

• 23% exhibit bicuspid aortic valves

hematopoietic system

thymus hypoplasia ( J:87304 )

• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

ectopic thymus ( J:87304 )

endocrine/exocrine glands

abnormal parathyroid gland morphology ( J:87304 )

• parathyroid ectopy, hypoplasia, and aplasia

absent parathyroid glands ( J:87304 )

• aplasia

ectopic parathyroid gland ( J:87304 )

parathyroid hypoplasia ( J:87304 )

thymus hypoplasia ( J:87304 )

• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

ectopic thymus ( J:87304 )

immune system

thymus hypoplasia ( J:87304 )

• exhibit thymic hypoplasia, however do not see bilateral thymic aplasia

ectopic thymus ( J:87304 )

craniofacial

abnormal pharyngeal arch artery morphology ( J:87304 )

• exhibit pharyngeal arch artery defects

abnormal fourth pharyngeal arch artery morphology ( J:87304 )

• defect in vascular tube formation in the fourth pharyngeal arch

enlarged third pharyngeal arch artery ( J:87304 )

• exhibit an abnormally large third pharyngeal arch artery

embryo

abnormal pharyngeal arch artery morphology ( J:87304 )

• exhibit pharyngeal arch artery defects

abnormal fourth pharyngeal arch artery morphology ( J:87304 )

• defect in vascular tube formation in the fourth pharyngeal arch

enlarged third pharyngeal arch artery ( J:87304 )

• exhibit an abnormally large third pharyngeal arch artery

abnormal neural crest cell apoptosis ( J:87304 )

• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8

cellular

abnormal neural crest cell apoptosis ( J:87304 )

• exhibit an increase in apoptosis of neural crest cells migrating from rhomobomeres 6-8

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Hoxa3^tm1(cre)Moon/Hoxa3⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dual inferior vena cava ( J:157946 )

abnormal dorsal mesocardium morphology ( J:157946 )

• inferior fusion defects resulting in notching of the inferior portion

total anomalous pulmonary venous connection ( J:157946 )

• rare but consistent phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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