Analysis Tools
mortality/aging
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• mice between E9.5 and E12.5, with most dead by E11.5
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cardiovascular system
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• at E10.5, intersomitic vessels and their branches are less organized and the number of secondary and tertiary branches are reduced
• at E10.5 branches of the internal carotid artery and the primary head veins are atretic
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• at E10.5 the density of vessels in the head is reduced
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• at E10.5 the labyrinth layer is less well vascularized , the penetration of the embryonic vessels is relatively superficial, and contact between embryonic and maternal vessels is reduced
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• markers of arteries and veins are ectopically expressed suggesting a defect in vessel specification
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• however, at E10 blood circulation through the dorsal aorta is normal
• at E10.5, dorsal aortae are smaller or collapsed
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• at E10.5 the number of secondary and tertiary branches of the intersomitic vessels are reduced and the branches of the internal carotid artery and the primary head veins are atretic
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• at E10.5 the cardinal veins are smaller or collapsed
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• at E10.5 larger branching vessels are absent and the density of small capillaries is significantly reduced
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• at E10.5 trabeculation of the bulbus cordis is reduced
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• at E10.5 the outer myocardial wall is thinner
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• at E10.5
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• at E10.5
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• dilated pericardial sac
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hemorrhage
(
J:152906
)
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• seen in various regions of the embryo at E10.5
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• hemorrhages are seen in the common cardinal veins at E10.5
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• at E10.5
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• hemorrhages are seen in the head at E10.5
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embryo
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• at E10.5 larger branching vessels are absent and the density of small capillaries is significantly reduced
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• some embryos show signs of growth retardation at E9.5 and all exhibit growth retardation by E10.5
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• at E10.5 the labyrinth layer is thinner and less well vascularized
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• at E10.5 the labyrinth layer is less well vascularized , the penetration of the embryonic vessels is relatively superficial, and contact between embryonic and maternal vessels is reduced
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• at E10.5 yolk sacs are thinner and lack obvious blood circulation
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• at E10.5 the primitive plexus has failed to remodel
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homeostasis/metabolism
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• at E10.5
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nervous system
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• at E10.5 the density of vessels in the head is reduced
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• hemorrhages are seen in the head at E10.5
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growth/size/body
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• some embryos show signs of growth retardation at E9.5 and all exhibit growth retardation by E10.5
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muscle
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• at E10.5 trabeculation of the bulbus cordis is reduced
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• at E10.5
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• at E10.5 the outer myocardial wall is thinner
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