Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nck1tm1Paw mutation
(2 available);
any
Nck1 mutation
(40 available)
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Assessment of atherosclerosis initiation and progression in tamoxifen-treated, high-fat diet fed Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw mice.
cardiovascular system
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• severity of lesions, atherosclerosis progression, and macrophage recruitment are reduced in male, but not female, following 16 weeks of a high-fat diet in tamoxifen-treated mice
• however, serum lipoprotein levels are normal
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immune system
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• severity of lesions, atherosclerosis progression, and macrophage recruitment are reduced in male, but not female, following 16 weeks of a high-fat diet in tamoxifen-treated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nck1tm1Paw mutation
(2 available);
any
Nck1 mutation
(40 available)
Nck2tm3Paw mutation
(0 available);
any
Nck2 mutation
(29 available)
Tg(Nphs2-cre)1Seq mutation
(0 available)
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growth/size/body
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• by 4 days of age, mutants are smaller than wild-type littermates; this is more apparent by 3 weeks of age
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homeostasis/metabolism
renal/urinary system
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• at 3.5 and 4.5 weeks of age, mutants show excessive amounts of albumin in their urine, indicating damage to the filtration barrier
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• by 3.5 weeks of age, loss of podocytes is observed
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• at E16.5, differentiated foot processes are absent in mutant embryos
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• in 4-day old mutants, there is complete fusion of foot processes around the capillary loops of the glomeruli
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• by 3.5 weeks of age, focal sclerosis and other defects are observed in the glomeruli
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• by 3.5 weeks of age, focal sclerosis is observed in the glomeruli
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• mutants have a buildup of proteinaceous material in the kidney tubules
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• damaged glomerular filtration barrier
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mortality/aging
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• mice die within a few days of birth with empty stomachs likely due to suckling defects
• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity
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nervous system
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• axons aberrantly re-cross the midline of the grey matter of the spinal cord
• interneurons aberrantly re-cross the midline of the spinal cord
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• reduced development of the posterior commissure noted at 12 weeks of age
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• axons aberrantly re-cross the midline of the grey matter of the spinal cord
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• mice exhibit a shallow dorsal funiculus and does not widen in adulthood compared to controls
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• mice exhibit synchronous firing of bilateral ventral motor neurons
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behavior/neurological
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• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity
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• mice exhibit a hoping gait that is maintained to adulthood
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growth/size/body
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• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity
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cellular
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• axons aberrantly re-cross the midline of the grey matter of the spinal cord
• interneurons aberrantly re-cross the midline of the spinal cord
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mortality/aging
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• no double homozygous mutant mice born
• double homozygotes present at Mendelian ratios at E8.5
• by E10.5 double homozygotes reduced to one third of expected
• no double homozygous mutant embryos by E12.5
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cellular
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• decreased fibroblast mobility
• actin fiber abnormalities
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embryo
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• deficient axial rotation
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• neural tube closure to level of otic vesicles but no further anteriorly
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• initial development is normal at the 2 to 4 somite stage
• degenerates rapidly after initial formation
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• growing toward headfold structures
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• allantois misshapen and balloon like
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• lack of chorioallantoic fusion
• due to misshapen allantois
• failure to develop definitive embryonic circulation
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nervous system
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• neural tube closure to level of otic vesicles but no further anteriorly
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Analysis Tools