All Phenotypes Pdgfra<tm8Sor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdgfra^tm8Sor
targeted mutation 8, Philippe Soriano
MGI:2449440

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823036
cn2	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823039
cn3	Pdgfra^tm8Sor/Pdgfra^tm8Sor Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:7545282
cn4	Mir140^tm1.1Tkob/Mir140^tm1.1Tkob Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Col2a1-cre)1Rsjo/0	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL	MGI:5086265
cn5	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm1Mdt/Pdgfrb^tm1Mdt H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C57BL/6 * CBA	MGI:3715096
cn6	Pdgfra^tm8Sor/Pdgfra^tm8Sor H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C57BL/6 * CBA	MGI:3715094
cn7	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Col2a1-cre)1Rsjo/0	involves: FVB/N	MGI:5086266
cn8	Pdgfra^tm8Sor/Pdgfra^tm8Sor Hoxa3^tm1(cre)Moon/Hoxa3⁺	Not Specified	MGI:7545278
cn9	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Leftb-cre)1Hmd/0	Not Specified	MGI:7545281
cn10	Pdgfra^tm8Sor/Pdgfra^tm8Sor H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	Not Specified	MGI:2450742

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Nr5a1-cre)2Klp/0
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142042 )

N	• phenotypes observed in testes and ovaries at 6 weeks of age are recoverable by 3 and 6 months of age

oligozoospermia ( J:142042 )

• few sperm are seen within the epididymis at 6 weeks of age

abnormal spermatocyte morphology ( J:142042 )

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

abnormal ovarian follicle morphology ( J:142042 )

• 6-8 week old females have decreased follicle development

decreased theca cell number ( J:142042 )

• 6-8 week old females have reduced numbers of theca cells in the maturing follicles of the ovaries, although a thin, broken theca interna is seen in the ovary

small ovary ( J:142042 )

• 6-8 week old females have small ovaries

abnormal testis morphology ( J:142042 )

• fewer steroid-producing cells are seen at E12.5-E14.5 in the testis

abnormal testis cord formation ( J:142042 )

• testis cord formation is delayed at E12.5-E14.5

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

decreased Leydig cell number ( J:142042 )

• reduction in number of adult Leydig cells at 6 weeks of age

small testis ( J:142042 )

• testes are smaller at 6 weeks of age but by 10 weeks they appear normal sized

uterus hypoplasia ( J:142042 )

• 6-8 week old females have underdeveloped uteri

delayed fertility ( J:142042 )

• delay in fertility, however by 3 to 6 months of age, mutants become fertile

anovulation ( J:142042 )

• 6-8 week old females show no evidence of ovlulation

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

• 6-8 week old females exhibit lower estradiol levels

abnormal testosterone level ( J:142042 )

• 75% of mutants exhibit low testosterone levels in the testes at 6 weeks of age, however by 10 weeks, levels are higher

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:142042 )

• 6-8 week old females have decreased follicle development

decreased theca cell number ( J:142042 )

• 6-8 week old females have reduced numbers of theca cells in the maturing follicles of the ovaries, although a thin, broken theca interna is seen in the ovary

small ovary ( J:142042 )

• 6-8 week old females have small ovaries

abnormal testis morphology ( J:142042 )

• fewer steroid-producing cells are seen at E12.5-E14.5 in the testis

abnormal testis cord formation ( J:142042 )

• testis cord formation is delayed at E12.5-E14.5

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

decreased Leydig cell number ( J:142042 )

• reduction in number of adult Leydig cells at 6 weeks of age

small testis ( J:142042 )

• testes are smaller at 6 weeks of age but by 10 weeks they appear normal sized

cellular

oligozoospermia ( J:142042 )

• few sperm are seen within the epididymis at 6 weeks of age

abnormal spermatocyte morphology ( J:142042 )

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Pdgfrb^tm11Sor mutation (1 available); any Pdgfrb mutation (84 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:142042 )

• few mutants are recovered after birth, however mutants are recovered at E18.5, indicating perinatal lethality

endocrine/exocrine glands

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

abnormal adrenal gland morphology ( J:142042 )

• reduction in steroid-producing cells in the adrenal glands at E18.5

abnormal adrenal cortex morphology ( J:142042 )

• reduction in adrenal cortex

small adrenal glands ( J:142042 )

• small adrenal glands are seen just before birth (E18.5)

abnormal testis morphology ( J:142042 )

• reduction in steroid-producing cells in the testis at E18.5

small testis ( J:142042 )

• small testes at E18.5

cardiovascular system

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

reproductive system

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

abnormal testis morphology ( J:142042 )

• reduction in steroid-producing cells in the testis at E18.5

small testis ( J:142042 )

• small testes at E18.5

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dual inferior vena cava ( J:157946 )

abnormal dorsal mesocardium morphology ( J:157946 )

• inferior fusion defects resulting in notching of the inferior portion

total anomalous pulmonary venous connection ( J:157946 )

• rare but consistent phenotype

Allelic Composition	Mir140^tm1.1Tkob/Mir140^tm1.1Tkob Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Col2a1-cre)1Rsjo/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir140^tm1.1Tkob mutation (0 available); any Mir140 mutation (1 available)
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Tg(Col2a1-cre)1Rsjo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:174096 )

• the skeletal defects observed in Mir140^tm1.1Tkob homozygotes are not rescued

decreased length of long bones ( J:174096 )

• compared with wild-type mice and Mir140^tm1.1Tkob homozygotes

growth/size/body

decreased body size ( J:174096 )

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm1Mdt/Pdgfrb^tm1Mdt H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Pdgfrb^tm1Mdt mutation (0 available); any Pdgfrb mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:122584 )

• 100% of mice die after birth

cardiovascular system

retroesophageal right subclavian artery ( J:122584 )

• in 100% of mice

persistent truncus arteriosus ( J:122584 )

• in 100% of mice

ventricular septal defect ( J:122584 )

• in 100% of mice

hematopoietic system

abnormal thymus development ( J:122584 )

• thymus development is aberrant

thymus hypoplasia ( J:122584 )

• thymus development is aberrant

craniofacial

cleft palate ( J:122584 )

• at birth

homeostasis/metabolism

cyanosis ( J:122584 )

• at birth

immune system

abnormal thymus development ( J:122584 )

• thymus development is aberrant

thymus hypoplasia ( J:122584 )

• thymus development is aberrant

digestive/alimentary system

cleft palate ( J:122584 )

• at birth

embryo

abnormal cardiac neural crest cell migration ( J:122584 )

• neural crest cell (NCC) migration defects occur in the conotruncus region

• NCCs fail to migrate to the thymic epithelium

cellular

abnormal cardiac neural crest cell migration ( J:122584 )

• neural crest cell (NCC) migration defects occur in the conotruncus region

• NCCs fail to migrate to the thymic epithelium

endocrine/exocrine glands

abnormal thymus development ( J:122584 )

• thymus development is aberrant

thymus hypoplasia ( J:122584 )

• thymus development is aberrant

growth/size/body

cleft palate ( J:122584 )

• at birth

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

retroesophageal right subclavian artery ( J:122584 )

• in 50% of mice

persistent truncus arteriosus ( J:122584 )

• in 25% of mice

delayed heart development ( J:122584 )

• cardiac development is delayed

ventricular septal defect ( J:122584 )

• in 75% of mice

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Col2a1-cre)1Rsjo/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Tg(Col2a1-cre)1Rsjo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased cranium height ( J:174096 )

abnormal skeleton development ( J:174096 )

• at P0.5, mice exhibit slightly greater mineralization of the talus compared with wild-type mice

• at P1.5, mineralization of the hyoid horn is more advanced than in wild-type mice

growth/size/body

decreased body weight ( J:174096 )

• mild

craniofacial

decreased cranium height ( J:174096 )

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Hoxa3^tm1(cre)Moon/Hoxa3⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm1(cre)Moon mutation (1 available); any Hoxa3 mutation (24 available)
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dual inferior vena cava ( J:157946 )

abnormal dorsal mesocardium morphology ( J:157946 )

• inferior fusion defects resulting in notching of the inferior portion

total anomalous pulmonary venous connection ( J:157946 )

• rare but consistent phenotype

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Leftb-cre)1Hmd/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Tg(Leftb-cre)1Hmd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dual inferior vena cava ( J:157946 )

abnormal dorsal mesocardium morphology ( J:157946 )

• inferior fusion defects resulting in notching of the inferior portion

total anomalous pulmonary venous connection ( J:157946 )

• rare but consistent phenotype

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:81153 )

cardiovascular system

abnormal vasculogenesis ( J:81153 )

• abnormal origin of the right subclavian artery

persistent truncus arteriosus ( J:81153 )

• observed between E17.7-E18.5

perimembraneous ventricular septal defect ( J:81153 )

hemorrhage ( J:81153 )

• midline hemorrhage

craniofacial

abnormal frontal bone morphology ( J:81153 )

• phenotype varied in severity; the frontal bones were absent or failed to fuse

abnormal nasal bone morphology ( J:81153 )

• phenotype varied in severity; the nasal bones were absent or failed to fuse

abnormal frontonasal prominence morphology ( J:81153 )

• developmental defects appear at E11.5 with a gap in the frontal nasal processes and progresses to hemorrhaging and blebbing by E13.5

abnormal nasal capsule morphology ( J:81153 )

• phenotype varied in severity; the nasal capsule was absent or failed to fuse

short snout ( J:81153 )

• snouts shortened by 8%

midline facial cleft ( J:81153 )

• phenotype varied in severity due to defects in the nasal capsule and/or frontal and nasal bones

immune system

small thymus ( J:81153 )

• observed with very low penetrance (3 out of 32 homozygous mutant embryos)

skeleton

abnormal frontal bone morphology ( J:81153 )

• phenotype varied in severity; the frontal bones were absent or failed to fuse

abnormal nasal bone morphology ( J:81153 )

• phenotype varied in severity; the nasal bones were absent or failed to fuse

abnormal nasal capsule morphology ( J:81153 )

• phenotype varied in severity; the nasal capsule was absent or failed to fuse

hematopoietic system

small thymus ( J:81153 )

• observed with very low penetrance (3 out of 32 homozygous mutant embryos)

respiratory system

abnormal nasal bone morphology ( J:81153 )

• phenotype varied in severity; the nasal bones were absent or failed to fuse

abnormal nasal capsule morphology ( J:81153 )

• phenotype varied in severity; the nasal capsule was absent or failed to fuse

endocrine/exocrine glands

small thymus ( J:81153 )

• observed with very low penetrance (3 out of 32 homozygous mutant embryos)

growth/size/body

abnormal nasal bone morphology ( J:81153 )

• phenotype varied in severity; the nasal bones were absent or failed to fuse

abnormal nasal capsule morphology ( J:81153 )

• phenotype varied in severity; the nasal capsule was absent or failed to fuse

short snout ( J:81153 )

• snouts shortened by 8%

midline facial cleft ( J:81153 )

• phenotype varied in severity due to defects in the nasal capsule and/or frontal and nasal bones

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