Phenotypes associated with this allele
Allelic Composition |
Disp1icb/Disp1icb
|
|
Genetic Background |
involves: 129/Sv * C57BL/6J * SWR |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation
(0 available);
any
Disp1 mutation
(61 available)
|
|
|
mortality/aging
|
• homozygotes die before E9.5
|
cardiovascular system
craniofacial
|
• gross defects in facial development are seen
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embryo
limbs/digits/tail
|
• gross defects in limb development are seen
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nervous system
|
• defects in neural development are seen
|
growth/size/body
|
• gross defects in facial development are seen
|
Allelic Composition |
Disp1icb/Disp1icb
|
|
Genetic Background |
involves: C3HeB/FeJ * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation
(0 available);
any
Disp1 mutation
(61 available)
|
|
|
mortality/aging
|
• embryos arrested at E9.0-E9.5
(J:79027)
|
cardiovascular system
|
• embryos lacked asymmetrical heart looping
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craniofacial
|
• embryos possessed abnormally shaped heads
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embryo
|
• embryonic turning occurred in a randomized direction
|
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• left-right randomization
|
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• neural tube was dorsalized
|
homeostasis/metabolism
limbs/digits/tail
|
• embryos possessed relatively large forelimbs
|
nervous system
|
• neural tube was dorsalized
|
growth/size/body
|
• embryos possessed abnormally shaped heads
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation
(0 available);
any
Disp1 mutation
(61 available)
Disp1tm1Amc mutation
(0 available);
any
Disp1 mutation
(61 available)
|
|
|
digestive/alimentary system
craniofacial
|
• loss of primary palate, premaxillary and nasal components
|
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• severe losses of frontal component
|
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• lack vomeronasal organs
|
endocrine/exocrine glands
respiratory system
|
• lack vomeronasal organs
|
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• nasopharyngeal airway narrowed or closed
|
skeleton
|
• loss of primary palate, premaxillary and nasal components
|
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• severe losses of frontal component
|
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• delayed differentiation in the cervical region
|
nervous system
|
• lack vomeronasal organs
|
growth/size/body
|
• severe midline facial defects by E10.5
|
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• lack vomeronasal organs
|
mortality/aging
craniofacial
|
• fusion of the nasal pits
|
|
• facial midline defects are seen
|
skeleton
nervous system
|
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type
|
embryo
respiratory system
|
• fusion of the nasal pits
|
cellular
|
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type
|
growth/size/body
|
• facial midline defects are seen
|
mortality/aging
|
• compound mutants die around birth unlike Disp1 single homozygotes which die before E9.5
|
craniofacial
|
• midline defects in the frontal nasal process are seen, however many of the developmental defects seen in Disp1 single homozygotes are rescued in the compound mutants
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation
(0 available);
any
Disp1 mutation
(61 available)
Disp1tm1Amc mutation
(0 available);
any
Disp1 mutation
(61 available)
Shhtm1(EGFP/cre)Cjt mutation
(1 available);
any
Shh mutation
(45 available)
|
|
|
limbs/digits/tail
|
• digit 2 is absent, all other digits are present
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation
(0 available);
any
Disp1 mutation
(61 available)
Ptch1tm1Mps mutation
(2 available);
any
Ptch1 mutation
(115 available)
|
|
|
mortality/aging
|
• embryos arrested at E9.0-9.5
|
nervous system
|
• neural tube was ventralized
|
embryo
|
• neural tube was ventralized
|
growth/size/body
|
• heads of the embryos appeared truncated
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation
(0 available);
any
Disp1 mutation
(61 available)
Disp1tm1Amc mutation
(0 available);
any
Disp1 mutation
(61 available)
Shhtm1Amc mutation
(1 available);
any
Shh mutation
(45 available)
|
|
|
cardiovascular system
|
• no heart looping but normal embryo turning
|
nervous system
|
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors
|
craniofacial
|
• extreme proboscis-like nasal process
|
growth/size/body
|
• extreme proboscis-like nasal process
|