Shh^tm5Amc
Targeted Allele Detail

Summary

• Symbol: Shh^tm5Amc
• Name: sonic hedgehog; targeted mutation 5, Andrew P McMahon
• MGI ID: MGI:3512786
• Synonyms: N-Shh^c
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm5Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed construct was inserted such that cre-mediated recombination results in the production of an allele that prematurely terminates, putatively precluding autoproteolytic activity and the associated process in which a cholesterol, involved in cell surface tethering, is attached to glycine 198. (J:94270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

References

• Original: J:94270 Tian H, et al., Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development. 2005 Jan;132(1):133-42
• All: 1 reference(s)