Phenotypes associated with this allele

• Allele Symbol: Foxp2⁺
• Allele Name: wild type
• Allele ID: MGI:2441314
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Foxp2^tm1Momo/Foxp2^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3789850
ht2	Foxp2^R552H/Foxp2^+	involves: BALB/c * C3H/HeH	MGI:3795716
ht3	Foxp2^tm1Bux/Foxp2^+	involves: C57BL/6	MGI:3584507
ht4	Foxp2^tm2.2Woen/Foxp2^+	involves: C57BL/6 * C57BL/6J	MGI:3851148

Genotype
MGI:3789850

ht1

• Allelic Composition: Foxp2^tm1Momo/Foxp2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Motor and ultrasonic vocalization impairment in Foxp2^tm1Momo/Foxp2^tm1Momo and Foxp2^tm1Momo/Foxp2⁺ mice

behavior/neurological

abnormal vocalization ( J:132813 )

• at P10, heterozygous pups show a modest impairment of ultrasonic vocalization when separated from mothers

• heterozygous pups produce three vocalizations, including whistle-type vocalizations similar to wild-type vocalizations, as well as short-length and click-type sonic vocalizations that are not normally seen in wild-type

growth/size/body

decreased body weight ( J:132813 )

• homozygotes show a 10-15% reduction in weight by P10

Genotype
MGI:3795716

ht2

• Allelic Composition: Foxp2^R552H/Foxp2⁺
• Genetic Background: involves: BALB/c * C3H/HeH

nervous system

reduced long-term depression ( J:135404 )

enhanced paired-pulse facilitation ( J:135404 )

behavior/neurological

abnormal motor learning ( J:135404 )

• motor skill learning on a running wheel is impaired compared to wild-type mice

Genotype
MGI:3584507

ht3

• Allelic Composition: Foxp2^tm1Bux/Foxp2⁺
• Genetic Background: involves: C57BL/6

Histological analysis of brains of Foxp2^tm1Bux and wild type mice

behavior/neurological

decreased vocalization ( J:99864 )

• at 6 days of age the incidence of vocalization over time is reduced and at 10 days of age a profound decrease in ultrasonic vocalizations is observed; however the duration, peak frequency, and bandwidth of the vocalizations are normal

nervous system

abnormal radial glial cell morphology ( J:99864 )

• radial glial fibers appear less well aligned and thinner

abnormal cerebellum external granule cell layer morphology ( J:99864 )

• a 1 cell thick external granule cell layer is seen at 15 - 17 days of age; however adult heterozygotes lack an external granule cell layer similar to wild-type mice

growth/size/body

postnatal growth retardation ( J:99864 )

cellular

abnormal radial glial cell morphology ( J:99864 )

• radial glial fibers appear less well aligned and thinner

Genotype
MGI:3851148

ht4

• Allelic Composition: Foxp2^tm2.2Woen/Foxp2⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J

behavior/neurological

decreased exploration in new environment ( J:150425 )

• on a modified hole board

abnormal eating behavior ( J:150425 )

abnormal response to novel object ( J:150425 )

• increased exploration of a novel object

decreased startle reflex ( J:150425 )

• mice react less to a clicking sound than wild-type mice

impaired coordination ( J:150425 )

• mice exhibit slightly impaired motor learning on a rotarod compared with wild-type mice

homeostasis/metabolism

abnormal circulating mineral level ( J:150425 )

• mice exhibit lower plasma inorganic phosphorus levels compared with wild-type mice

increased circulating ferritin level ( J:150425 )

• mice exhibit a slightly higher plasma Ferritin levels compared with wild-type mice

increased dopamine level ( J:150425 )

• in the frontal cortex, cerebellum, caudate-putamen, nucleus accumbens, and globus pallidus

abnormal energy homeostasis ( J:150425 )

• mice assimilate more energy than wild-type mice

increased serotonin level ( J:150425 )

• increased in the frontal cortex, cerebellum, caudate-putamen, nucleus accumbens, and globus pallidus

respiratory system

increased pulmonary respiratory rate ( J:150425 )

• mice exhibit higher respiratory rate during activity and at rest compared with wild-type mice

immune system

increased CD4-positive, alpha-beta T cell number ( J:150425 )

increased CD8-positive, alpha-beta T cell number ( J:150425 )

adipose tissue

decreased total fat pad weight ( J:150425 )

cardiovascular system

abnormal cardiovascular system physiology ( J:150425 )

• mice exhibit a lower pulse rate than wild-type mice

growth/size/body

decreased lean body mass ( J:150425 )

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:150425 )

increased CD8-positive, alpha-beta T cell number ( J:150425 )