About   Help   FAQ
Targeted Allele Detail
Symbol: Foxp2tm1Momo
Name: forkhead box P2; targeted mutation 1, Takashi Momoi
MGI ID: MGI:3778383
Synonyms: FoxP2R552H
Gene: Foxp2  Location: Chr6:14901348-15441976 bp, + strand  Genetic Position: Chr6, 6.49 cM, cytoband A2
Alliance: Foxp2tm1Momo page
Small body and cerebellum size and abnormal cerebellar foliation in Foxp2tm1Momo/Foxp2tm1Momo mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:132813
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
Mutation detailsExon 17 was replaced with an exon 17 that contained a nucleotide substitution resulting in an amino acid substitution of histidine for arginine at position 552 (R552H). A floxed neo cassette was inserted downstream of exon 17 but was removed by transient cre expression. This mutation corresponds to human mutation R553H of FOXP2 that results in speech-language disorders. (J:132813)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Foxp2 Mutation:  52 strains or lines available
Original:  J:132813 Fujita E, et al., Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3117-22
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory