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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp2tm1Momo
targeted mutation 1, Takashi Momoi
MGI:3778383
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Foxp2tm1Momo/Foxp2tm1Momo involves: 129S6/SvEvTac * C57BL/6 MGI:3789843
ht2
Foxp2tm1Momo/Foxp2+ involves: 129S6/SvEvTac * C57BL/6 MGI:3789850


Genotype
MGI:3789843
hm1
Allelic
Composition
Foxp2tm1Momo/Foxp2tm1Momo
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp2tm1Momo mutation (2 available); any Foxp2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Small body and cerebellum size and abnormal cerebellar foliation in Foxp2tm1Momo/Foxp2tm1Momo mice

mortality/aging
• approximately half of homozygotes are embryonic lethal or die at birth
• approximately half of homozygotes are embryonic lethal or die at birth

growth/size/body
• homozygotes are about 30% smaller than wild-type at P10
• at P10, homozygotes show a 30-40% reduction in mean weight, with a further weight reduction over the next 10 days
• homozygotes do not grow at a normal rate 20 days after birth

behavior/neurological
• homozygotes at P8-P10 show severe motor abnormalities, such as decreased spontaneous activity and sudden irregular and discoordinated movements
• by P14-P20, homozygotes are nearly unable to perform activities
• homozygotes are delayed in their ability to right themselves when placed on their backs or in midair
• homozygotes show a difference from wild-type in the midair-righting assay
• decrease in spontaneous activity at P8-P10
• at P10, mutant pups show severe impairment of ultrasonic vocalization when separated from mothers, producing only a few click-like vocalizations
• at P14-P20, do not produce any ultrasonic vocalization because of the severe loss of activity

nervous system
• development of folia of the cerebellum is immature with less folia that are incompletely folded
• calbindin-positive Purkinje cells are aligned in a continuous row but are sparsely localized in the folia
• dendritic shafts of Purkinje cells are thin, with less elaborated calbindin-positive dendritic arbors and reduced synaptophysin reactivity
• dendrites remain at an immature level at P19




Genotype
MGI:3789850
ht2
Allelic
Composition
Foxp2tm1Momo/Foxp2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp2tm1Momo mutation (2 available); any Foxp2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Motor and ultrasonic vocalization impairment in Foxp2tm1Momo/Foxp2tm1Momo and Foxp2tm1Momo/Foxp2+ mice

behavior/neurological
• at P10, heterozygous pups show a modest impairment of ultrasonic vocalization when separated from mothers
• heterozygous pups produce three vocalizations, including whistle-type vocalizations similar to wild-type vocalizations, as well as short-length and click-type sonic vocalizations that are not normally seen in wild-type

growth/size/body
• homozygotes show a 10-15% reduction in weight by P10





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory