All Phenotypes Adamts9<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adamts9⁺
wild type
MGI:2440526

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Adamts9^Mhdaund3/Adamts9⁺	C3HeB/FeJ-Adamts9^Mhdaund3	MGI:6163983
ht2	Adamts9^Mhdaund3/Adamts9⁺	C3HeB/FeJ-Adamts9^Mhdaund3/Ieg	MGI:3716902
ht3	Adamts9^Mhdaund4/Adamts9⁺	C3HeB/FeJ-Adamts9^Mhdaund4	MGI:6163978
ht4	Adamts9^{tm1b(KOMP)Wtsi}/Adamts9⁺	C57BL/6N-Adamts9^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:6325107
ht5	Adamts9^{tm1b(KOMP)Wtsi}/Adamts9⁺	C57BL/6N-Adamts9^{tm1b(KOMP)Wtsi}/Mmucd	MGI:5797337
ht6	Adamts9^tm1.2Apte/Adamts9⁺	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603306
ht7	Adamts9^tm1.2Cvrk/Adamts9⁺	involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6NTac * FVB/N	MGI:6163993
cx8	Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺	B6.129P2-Adamts9^tm1Dgen Adamts5^tm1Dgen	MGI:4418860
cx9	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1	MGI:4418877
cx10	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺ Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418865
cx11	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418861
cx12	Adamts20^bt-2H/Adamts20^bt-2H Adamts9^tm1Dgen/Adamts9⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4418869
cx13	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9⁺	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603312
cx14	Adamts9^tm1.2Apte/Adamts9⁺ B3glct^tm1.2Nari/B3glct^tm1.2Nari	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac * DBA/2 * SJL	MGI:6407447
cx15	Adamts9^Mhdaund3/Adamts9⁺ Tg(Dct-lacZ)A12Jkn/0	involves: C3HeB/FeJ * C57BL/6 * CBA	MGI:6163984
cx16	Adamts9^Mhdaund4/Adamts9⁺ Tg(Dct-lacZ)A12Jkn/0	involves: C3HeB/FeJ * C57BL/6 * CBA	MGI:6163981

Allelic Composition	Adamts9^Mhdaund3/Adamts9⁺
Genetic Background	C3HeB/FeJ-Adamts9^Mhdaund3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^Mhdaund3 mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

integument

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

limbs/digits/tail

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

Allelic Composition	Adamts9^Mhdaund3/Adamts9⁺
Genetic Background	C3HeB/FeJ-Adamts9^Mhdaund3/Ieg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^Mhdaund3 mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal tail pigmentation ( J:86685 )

• white ring around tail

integument

abnormal tail pigmentation ( J:86685 )

• white ring around tail

limbs/digits/tail

abnormal tail pigmentation ( J:86685 )

• white ring around tail

Allelic Composition	Adamts9^Mhdaund4/Adamts9⁺
Genetic Background	C3HeB/FeJ-Adamts9^Mhdaund4

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^Mhdaund4 mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

integument

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

limbs/digits/tail

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

Allelic Composition	Adamts9^{tm1b(KOMP)Wtsi}/Adamts9⁺
Genetic Background	C57BL/6N-Adamts9^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0658_5_D12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^{tm1b(KOMP)Wtsi} mutation (0 available); any Adamts9 mutation (90 available)

Data Sources

IMPC Data for Adamts9

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymph node morphology ( J:211773 )

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - UCD

Allelic Composition	Adamts9^{tm1b(KOMP)Wtsi}/Adamts9⁺
Genetic Background	C57BL/6N-Adamts9^{tm1b(KOMP)Wtsi}/Mmucd
Cell Lines	EPD0658_5_D12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^{tm1b(KOMP)Wtsi} mutation (0 available); any Adamts9 mutation (90 available)

Data Sources

IMPC Data for Adamts9

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

Allelic Composition	Adamts9^tm1.2Apte/Adamts9⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart valve morphology ( J:213412 )

• cardiac valve abnormalities

limbs/digits/tail

limbs/digits/tail phenotype ( J:213412 )

N	• soft tissue syndactly is not observed

vision/eye

abnormal eye morphology ( J:213412 )

• eye defects

Allelic Composition	Adamts9^tm1.2Cvrk/Adamts9⁺
Genetic Background	involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6NTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Cvrk mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal tail pigmentation ( J:262498 )

• unpigmented tail rings in 5 of 7 mice

integument

abnormal tail pigmentation ( J:262498 )

• unpigmented tail rings in 5 of 7 mice

limbs/digits/tail

abnormal tail pigmentation ( J:262498 )

• unpigmented tail rings in 5 of 7 mice

Allelic Composition	Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.129P2-Adamts9^tm1Dgen Adamts5^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5^tm1Dgen mutation (1 available); any Adamts5 mutation (56 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 87% penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 100% penetrance of soft-tissue syndactyly (STS, n=5)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺ Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5^tm1Dgen mutation (1 available); any Adamts5 mutation (56 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• partial penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• fully penetrant soft-tissue syndactyly (STS)

• more affected limbs than littermate control

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-2H/Adamts20^bt-2H Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-2H mutation (2 available); any Adamts20 mutation (93 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:133403 )

• die shortly after birth

pigmentation

abnormal coat/hair pigmentation ( J:133403 )

• de-pigmentation is apparent on 75% of the anterior-posterior length (n=5) in the trunk skin samples from newborn mutants

embryo

abnormal melanoblast morphology ( J:133403 )

• significant reduction in melanoblasts in the trunk and head region of E13.5 embryos

nervous system

abnormal melanoblast morphology ( J:133403 )

• significant reduction in melanoblasts in the trunk and head region of E13.5 embryos

integument

abnormal coat/hair pigmentation ( J:133403 )

• de-pigmentation is apparent on 75% of the anterior-posterior length (n=5) in the trunk skin samples from newborn mutants

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

digestive/alimentary system

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

embryo

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

growth/size/body

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

integument

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

limbs/digits/tail

syndactyly ( J:213412 )

• soft tissue syndactly

nervous system

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

pigmentation

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

Allelic Composition	Adamts9^tm1.2Apte/Adamts9⁺ B3glct^tm1.2Nari/B3glct^tm1.2Nari
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)
B3glct^tm1.2Nari mutation (0 available); any B3glct mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:286130 )

craniofacial

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

digestive/alimentary system

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

growth/size/body

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

vision/eye

abnormal eye morphology ( J:286130 )

• late gestation embryos show eye abnormalities ranging from small eye and/or pupil to absent pupil and/or eye

microphthalmia ( J:286130 )

• small eyes in some mutants

anophthalmia ( J:286130 )

• eyes are absent is some mutants

Allelic Composition	Adamts9^Mhdaund3/Adamts9⁺ Tg(Dct-lacZ)A12Jkn/0
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^Mhdaund3 mutation (1 available); any Adamts9 mutation (90 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

integument

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

limbs/digits/tail

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

Allelic Composition	Adamts9^Mhdaund4/Adamts9⁺ Tg(Dct-lacZ)A12Jkn/0
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^Mhdaund4 mutation (1 available); any Adamts9 mutation (90 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal epidermal pigmentation ( J:262498 )

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• however, distribution of melanoblasts in the dermis is normal

embryo

abnormal melanoblast morphology ( J:262498 )

• at E18.5/P0, all mice exhibit an area of reduced melanoblasts in the tail compared with just over half of wild-type mice

• at P2, most mice exhibit an area of reduced melanoblasts in the tail compared with few wild-type mice

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• the boundaries of hypopigmentation are stable over time

• at P28, hypopigmented epidermis in the skin contains no lacZ-positive cells in the scales or hair with some scales at the edge being lightly pigmented and containing less dendritic melanocytes

• however, melanoblast distribution in the tail is normal at E16.5 and distribution of melanoblasts in the dermis is normal

integument

abnormal epidermal pigmentation ( J:262498 )

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• however, distribution of melanoblasts in the dermis is normal

nervous system

abnormal melanoblast morphology ( J:262498 )

• at E18.5/P0, all mice exhibit an area of reduced melanoblasts in the tail compared with just over half of wild-type mice

• at P2, most mice exhibit an area of reduced melanoblasts in the tail compared with few wild-type mice

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• the boundaries of hypopigmentation are stable over time

• at P28, hypopigmented epidermis in the skin contains no lacZ-positive cells in the scales or hair with some scales at the edge being lightly pigmented and containing less dendritic melanocytes

• however, melanoblast distribution in the tail is normal at E16.5 and distribution of melanoblasts in the dermis is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/13/2026 MGI 6.24