B3glct^tm1.2Nari
Targeted Allele Detail

Summary

• Symbol: B3glct^tm1.2Nari
• Name: beta-3-glucosyltransferase; targeted mutation 1.2, Hirashi Narimatsu
• MGI ID: MGI:6277079
• Synonyms: B3glct-delta11-12, B3glct^tm1.3Nari
• Gene: B3glct Location: Chr5:149601695-149686064 bp, + strand Genetic Position: Chr5, 89.18 cM
• Alliance: B3glct^tm1.2Nari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286130
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 11 and 12 were flanked by loxP sites. An FRT, neomycin selection cassette, loxP, and second FRT site were inserted downstream of the floxed exons. Flp-mediated recombination removed neomycin cassette. Cre-mediated recombination deleted exons 11 and 12. (J:286130)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B3glct Mutation: 48 strains or lines available

References

• Original: J:286130 Holdener BC, et al., ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome. Hum Mol Genet. 2019 Dec 15;28(24):4053-4066
• All: 1 reference(s)