Adamts5^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Adamts5^tm1Dgen
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 5; targeted mutation 1, Deltagen
• MGI ID: MGI:3604488
• Synonyms: Adamts5^deltacat, ts5^-
• Gene: Adamts5 Location: Chr16:85655045-85698013 bp, - strand Genetic Position: Chr16, 48.34 cM
• Alliance: Adamts5^tm1Dgen page

Mutation origin

• Mutant Cell Line: 8491
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene was inserted into and replaced 134 nucleotides of exon 2. The deleted region includes sequences encoding the catalytic active site as well as most of the putative muscle regulatory factor-binding enhancer. The highest levels of RNA transcripts are detectable in pancreas, adrenal gland and white fat. Moderate levels of RNA transcripts are detectable in: olfactory bulb, heart, lung, thymus, skin, gallbladder, testis, epididymis and coagulating gland. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, subcortical region, cerebellum, brainstem, spinal cord, eye, Harderian glands, liver, kidney, spleen, lymph nodes, bone marrow, urinary bladder, pituitary gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, seminal vesicle, prostate gland and uterus. LacZ expression was detected in all organs examined. (J:148803)

Expression

In Mice Carrying this Mutation:	321 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adamts5 Mutation: 54 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 24 reference(s)