Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
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limbs/digits/tail
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• 44% penetrance of soft-tissue syndactyly (STS)
• hindlimbs are more frequently affected
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limbs/digits/tail
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• 100% incidence of soft tissue syndactyly
• phenotype is more severe than in either allele alone
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
Adamts9tm1Dgen mutation
(0 available);
any
Adamts9 mutation
(90 available)
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limbs/digits/tail
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• 87% penetrance of soft-tissue syndactyly (STS)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation
(0 available);
any
Adamts20 mutation
(93 available)
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
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limbs/digits/tail
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• partial penetrance of soft-tissue syndactyly (STS)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation
(0 available);
any
Adamts20 mutation
(93 available)
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
|
|
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limbs/digits/tail
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• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections
• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs
• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant
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• soft-tissue syndactyly (STS) with 100% penetrance
• at least three of four limbs are involved
• the interdigital tissue (IDT) between hindlimb digits 3 and 4 is most frequently involved and has the greatest severity of STS
• persistence of the IDT with a low cell density and loose, amorphous matrix
• reduced versican clearance
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• syndactyly is caused by the persistence of the skin web between the digits
• no osseous syndactyly or patterning defects
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cellular
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• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections
• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs
• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation
(0 available);
any
Adamts20 mutation
(93 available)
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
|
|
|
limbs/digits/tail
|
• partial penetrance of soft-tissue syndactyly (STS)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation
(0 available);
any
Adamts20 mutation
(93 available)
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
|
|
|
limbs/digits/tail
|
• partial penetrance of soft-tissue syndactyly (STS)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation
(0 available);
any
Adamts20 mutation
(93 available)
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
Adamts9tm1Dgen mutation
(0 available);
any
Adamts9 mutation
(90 available)
|
|
|
limbs/digits/tail
|
• partial penetrance of soft-tissue syndactyly (STS)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation
(0 available);
any
Adamts20 mutation
(93 available)
Adamts5tm1Dgen mutation
(1 available);
any
Adamts5 mutation
(54 available)
Adamts9tm1Dgen mutation
(0 available);
any
Adamts9 mutation
(90 available)
|
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limbs/digits/tail
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• fully penetrant soft-tissue syndactyly (STS)
• more affected limbs than littermate control
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