About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adamts5tm1Dgen
targeted mutation 1, Deltagen
MGI:3604488
Summary 9 genotypes


Genotype
MGI:4418754
hm1
Allelic
Composition
Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic
Background
B6.129P2-Adamts5tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 44% penetrance of soft-tissue syndactyly (STS)
• hindlimbs are more frequently affected




Genotype
MGI:5603313
cn2
Allelic
Composition
Adamts5tm1Dgen/Adamts5tm1Dgen
Adamts9tm1.1Apte/Adamts9tm1.1Apte
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
Adamts9tm1.1Apte mutation (1 available); any Adamts9 mutation (90 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 100% incidence of soft tissue syndactyly
• phenotype is more severe than in either allele alone




Genotype
MGI:4418860
cx3
Allelic
Composition
Adamts5tm1Dgen/Adamts5tm1Dgen
Adamts9tm1Dgen/Adamts9+
Genetic
Background
B6.129P2-Adamts9tm1Dgen Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
Adamts9tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 87% penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418759
cx4
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5+
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418858
cx5
Allelic
Composition
Adamts20bt-Bei1/Adamts20bt-Bei1
Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections
• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs
• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant
• soft-tissue syndactyly (STS) with 100% penetrance
• at least three of four limbs are involved
• the interdigital tissue (IDT) between hindlimb digits 3 and 4 is most frequently involved and has the greatest severity of STS
• persistence of the IDT with a low cell density and loose, amorphous matrix
• reduced versican clearance
• syndactyly is caused by the persistence of the skin web between the digits
• no osseous syndactyly or patterning defects

cellular
• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections
• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs
• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant




Genotype
MGI:4418757
cx6
Allelic
Composition
Adamts20bt-Bei1/Adamts20bt-Bei1
Adamts5tm1Dgen/Adamts5+
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418755
cx7
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418865
cx8
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5+
Adamts9tm1Dgen/Adamts9+
Genetic
Background
B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
Adamts9tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418861
cx9
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5tm1Dgen
Adamts9tm1Dgen/Adamts9+
Genetic
Background
B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
Adamts9tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• fully penetrant soft-tissue syndactyly (STS)
• more affected limbs than littermate control





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory