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Allele Symbol Allele Name Allele ID |
Tagln+ wild type MGI:2440350 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal Mendelian ratio after weaning
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| N |
• mice exhibit normal retinal vascular development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• superficial temporal artery is more branched than in controls
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• at E11.5, carotid artery (CA) overbranching is observed
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• vertebral artery (VA) caliber is increased relative to controls
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• number of smooth muscle actin-positive cells in CA is half that observed in controls
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• in the head, aneurysms are frequently observed
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• in the head, hemorrhages are frequently observed
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• number of smooth muscle actin-positive cells in CA is half that observed in controls
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• in the head, hemorrhages are frequently observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• aortic root shows a approximate 30% reduction in lesion area and necrotic area compared to Apoetm1Unc Ddit3tm1.1Irt double homozygotes, indicating decreased atherosclerotic plaque progression
• smooth muscle cell content is lower in aortic arch lesions compared to Ddit3tm1.1Irt Apoetm1Unc double homozygotes
• mice on a Western diet show a lower content of alpha-actin-positive vascular smooth muscle cells in the lesions compared to Ddit3tm1.1Irt Apoetm1Unc double homozygotes
• lesions show decreased vascular smooth muscle cell proliferation
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| N |
• after 12 weeks of Western diet feeding, mice exhibit similar body weight, blood glucose, total plasma cholesterol, HDL cholesterol, plasma triglycerides, and blood pressure as Apoetm1Unc Ddit3tm1.1Irt double homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased carotid artery section surface (increased vessel diameter) is observed
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• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed
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• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• almost 50% of tamoxifen-treated animals die by 18 months from gastrointestinal obstruction (average lifespan 13.5 months); widespread gastrointestinal polyposis is found at time of necropsy
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| N |
• with 2 intraperitoneal injections of tamoxifen at 6 weeks of age, no abnormalities are seen at 3 and 8 months of age
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• at 11 months, gastrointestinal tract polyps are observed in <60% of tamoxifen-treated animals
• average polyp size is smaller than in Stk11tm1.2Rdp/+ mice at 11 months
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• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls
• tumors are characterized by a smooth muscle core, abundant stroma and hyperplastic epithelia without dysplasia
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• at 11 months, mice present with severe gastrointestinal obstruction
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• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls
• tumors are characterized by a smooth muscle core, abundant stroma and hyperplastic epithelia without dysplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 75% of tamoxifen-treated animals develop gastrointestinal polyposis by 11 months
• average size of polyps is comparable to that seen in double heterozygotes
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• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls
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• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
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• less developed branching network of subepicardial conduit vessels
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• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
• reduced overall diameter of the coronary stems and reduced branching index
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• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have a median survival time of 52 weeks
• this survival time is significantly longer than Prkg1tm2.1Naw homozygote that do not carry the knock-in allele
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• female mice have a reduced success rate of pregnancy
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• mice have slightly reduced litter size of 3 to 6 pups
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have a median survival time of 52 weeks
• this survival time is significantly longer than Prkg1tm2.1Naw homozygote that do not carry the knock-in allele
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• female mice have a reduced success rate of pregnancy
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• mice have slightly reduced litter size of 3 to 6 pups
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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