Tagln^{tm2(PRKG1*)Hfm}
Targeted Allele Detail

Summary

• Symbol: Tagln^{tm2(PRKG1*)Hfm}
• Name: transgelin; targeted mutation 2, Franz Hofmann
• MGI ID: MGI:3790081
• Synonyms: SM22alpha^Ibeta, SM22^Ibeta, SMcGKIbeta
• Gene: Tagln Location: Chr9:45840926-45847356 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Tagln^{tm2(PRKG1*)Hfm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134928
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The cDNA for bovine PRKG1 isoform beta was inserted immediately downstream of the start methionine followed by a neo cassette. The insertion results in the mutation of glycine 2 of the bovine cDNA to an arginine. Expression of the bovine protein in smooth muscle cells was confirmed by western blot analysis. (J:134928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tagln Mutation: 26 strains or lines available

References

• Original: J:134928 Weber S, et al., Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circ Res. 2007 Nov 26;101(11):1096-103
• All: 11 reference(s)