All Phenotypes Ar<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ar⁺
wild type
MGI:2439066

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ar^tm4(AR)Dmr/Ar⁺	involves: 129S1/Sv * C57BL/6J	MGI:3814236
cn2	Ar^tm2.1Reb/Ar⁺ Tg(Amh-cre)8815Reb/?	129S(FVB)-Ar^tm2.1Reb	MGI:5571719
cn3	Ar^tm1Chc/Ar⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: 129S/SvEv * C57BL/6J * FVB/N	MGI:3773445
cx4	Ar^Tfm/Ar⁺ Eda^Ta-25H/Eda⁺	involves: 101/H * C3H/HeH	MGI:4459540
cx5	Ar^Tfm/Ar⁺ Lactb2^{Tg(Igh-Meis1)2770Amb}/Lactb2^{Tg(Igh-Meis1)2770Amb}	involves: FVB/NJ	MGI:3795905

Allelic Composition	Ar^tm4(AR)Dmr/Ar⁺
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm4(AR)Dmr mutation (0 available); any Ar mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:114552 )

N	• unlike hemizygous mutant males most of which exhibit early death at 2-4 months of age, heterozygous mutant females display a normal life span • testosterone-treated heterozygous mutant females show survival rates similar to those of wild-type, untreated or vehicle-treated control females

behavior/neurological

decreased grip strength ( J:114552 )

• at 16 months of age, testosterone-treated heterozygous mutant females display a small but significant deficit in forelimb grip strength but unchanged body mass relative to vehicle-treated control females

homeostasis/metabolism

increased circulating testosterone level ( J:114552 )

• at 4-7 months of age, testosterone-treated heterozygous mutant females show significantly increased serum testosterone levels relative to vehicle-treated and wild-type control females

increased urine major urinary protein level ( J:114552 )

• testosterone-treated heterozygous mutant females excrete higher levels of major urinary proteins than vehicle-treated control females

muscle

muscle weakness ( J:114552 )

• heterozygous mutant females develop androgen-dependent neuromuscular weakness in the absence of early death

renal/urinary system

increased urine major urinary protein level ( J:114552 )

• testosterone-treated heterozygous mutant females excrete higher levels of major urinary proteins than vehicle-treated control females

growth/size/body

growth/size/body region phenotype ( J:114552 )

N	• at 16 months of age, testosterone-treated heterozygous mutant females display body weights similar to those of vehicle-treated control females

Allelic Composition	Ar^tm2.1Reb/Ar⁺ Tg(Amh-cre)8815Reb/?
Genetic Background	129S(FVB)-Ar^tm2.1Reb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2.1Reb mutation (2 available); any Ar mutation (23 available)
Tg(Amh-cre)8815Reb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell barrier morphology ( J:210656 )

• seminiferous tubules have stretches of severely disorganized Sertoli cell tight junctions interspersed with intact areas

• preleptotene spermatocytes are enclosed in incomplete Sertoli cell tight junction compartments

abnormal Sertoli cell barrier function ( J:210656 )

• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

reproductive system

abnormal Sertoli cell barrier morphology ( J:210656 )

• seminiferous tubules have stretches of severely disorganized Sertoli cell tight junctions interspersed with intact areas

• preleptotene spermatocytes are enclosed in incomplete Sertoli cell tight junction compartments

abnormal Sertoli cell barrier function ( J:210656 )

• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

Allelic Composition	Ar^tm1Chc/Ar⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm1Chc mutation (0 available); any Ar mutation (23 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased litter size ( J:81789 )

• litters from heterozygous females have fewer pups compared to those of control females

Allelic Composition	Ar^Tfm/Ar⁺ Eda^Ta-25H/Eda⁺
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^Tfm mutation (1 available); any Ar mutation (23 available)
Eda^Ta-25H mutation (0 available); any Eda mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:11266 )

prenatal lethality, incomplete penetrance ( J:11266 )

pigmentation

abnormal coat/hair pigmentation ( J:11266 )

• mice of this genotype appear to have black stripes

• this class is underrepresented at weaning

irregular coat pigmentation ( J:11266 )

• Background Sensitivity: black transverse markings are seen, variable in extent and location due to X-inactivation

transverse fur striping ( J:11266 )

growth/size/body

supernumerary incisors ( J:11266 )

decreased body size ( J:11266 )

• frequently small and runted

craniofacial

abnormal cranium size ( J:11266 )

• shortened with lateral distortion

supernumerary incisors ( J:11266 )

domed cranium ( J:11266 )

skeleton

abnormal cranium size ( J:11266 )

• shortened with lateral distortion

supernumerary incisors ( J:11266 )

domed cranium ( J:11266 )

limbs/digits/tail

polydactyly ( J:11266 )

• occasionally indications in the region of the hallux of the rear feet

syndactyly ( J:11266 )

• involving predominantly digits 1 and 2 of both or either front or rear feet

nervous system

exencephaly ( J:11266 )

• detected in some mice during fetal development

integument

abnormal coat/hair pigmentation ( J:11266 )

• mice of this genotype appear to have black stripes

• this class is underrepresented at weaning

irregular coat pigmentation ( J:11266 )

• Background Sensitivity: black transverse markings are seen, variable in extent and location due to X-inactivation

transverse fur striping ( J:11266 )

striated fur ( J:11266 )

• Background Sensitivity: transverse black banding characterizes the appearance of this mouse on an agouti background

Allelic Composition	Ar^Tfm/Ar⁺ Lactb2^{Tg(Igh-Meis1)2770Amb}/Lactb2^{Tg(Igh-Meis1)2770Amb}
Genetic Background	involves: FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^Tfm mutation (1 available); any Ar mutation (23 available)
Lactb2^{Tg(Igh-Meis1)2770Amb} mutation (0 available); any Lactb2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:79618 )

N	• mice survive at least 200 days unlike Lactb2^{Tg(Igh-Meis1)2770Amb} homozygotes

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