Ar^tm2.1Reb
Targeted Allele Detail

Summary

• Symbol: Ar^tm2.1Reb
• Name: androgen receptor; targeted mutation 2.1, Robert E Braun
• MGI ID: MGI:5431884
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm2.1Reb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210656
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 1 and the Ar start site, and a frt-flanked neomycin resistance (neo) cassette, followed by another loxP site, downstream of exon 1. Flp-mediated recombination removed the neo cassette. (J:210656)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 22 strains or lines available

References

• Original: J:210656 Chakraborty P, et al., Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol. 2014 Jul;28(7):1055-72
• All: 5 reference(s)