Lactb2^{Tg(Igh-Meis1)2770Amb}
Transgenic Allele Detail

Summary

• Symbol: Lactb2^{Tg(Igh-Meis1)2770Amb}
• Name: lactamase, beta 2; transgene insertion 2770, Arthur M Buchberg
• MGI ID: MGI:3793472
• Synonyms: Tg2770
• Gene: Lactb2 Location: Chr1:13695069-13730749 bp, - strand Genetic Position: Chr1, 4.29 cM
• Alliance: Lactb2^{Tg(Igh-Meis1)2770Amb} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Lactb2^{Tg(Igh-Meis1)2770Amb} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Meis1 (MGI:104717)

• Mutation details: A transgene was constructed in which the Igh promoter and enhancers were used to drive expression of the Meis1 cDNA (transcript a). Sequencing of line 2770 revealed the integration site to be located within Lactb replacing a 21.3 kb segment containing exons 5 through 7. (J:79618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lactb2 Mutation: 20 strains or lines available

References

• Original: J:79618 Sollars VE, et al., A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Hum Mol Genet. 2002 Nov 1;11(22):2777-86
• All: 1 reference(s)