All Phenotypes Grem1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grem1⁺
wild type
MGI:2438115

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Grem1^tm1Ecan/Grem1⁺ Nog^tm1.1Rmh/Nog^tm1.1Rmh Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL	MGI:4941476
cx2	Grem1^tm1Rmh/Grem1⁺ Rr26^tm1Svok/Rr26⁺	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5562301
cx3	Fmn1^tm2Made/Fmn1⁺ Grem1^tm1Azun/Grem1⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:3848990
cx4	Alx4^lst/Alx4⁺ Grem1^ld-J/Grem1⁺	involves: CBA/Ca * NHO	MGI:4355958
cx5	Alx4^lst/Alx4⁺ Grem1^ld/Grem1⁺	Not Specified	MGI:4355956

Allelic Composition	Grem1^tm1Ecan/Grem1⁺ Nog^tm1.1Rmh/Nog^tm1.1Rmh Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1^tm1Ecan mutation (0 available); any Grem1 mutation (19 available)
Nog^tm1.1Rmh mutation (1 available); any Nog mutation (18 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:169133 )

• at E8.5 and E9.5, mice exhibit buckled neural tubes that frequently fail to close anteriorly unlike in wild-type mice

open neural tube ( J:169133 )

• anteriorly in some mice

embryo

abnormal neural tube morphology ( J:169133 )

• at E8.5 and E9.5, mice exhibit buckled neural tubes that frequently fail to close anteriorly unlike in wild-type mice

open neural tube ( J:169133 )

• anteriorly in some mice

decreased somite size ( J:169133 )

• at E8.5 and E9.5, mice exhibit small posterior somites compared with wild-type mice

Allelic Composition	Grem1^tm1Rmh/Grem1⁺ Rr26^tm1Svok/Rr26⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1^tm1Rmh mutation (1 available); any Grem1 mutation (19 available)
Rr26^tm1Svok mutation (0 available); any Rr26 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:207959 )

N	• mice exhibit normal skeletal patterning

Allelic Composition	Fmn1^tm2Made/Fmn1⁺ Grem1^tm1Azun/Grem1⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmn1^tm2Made mutation (1 available); any Fmn1 mutation (73 available)
Grem1^tm1Azun mutation (1 available); any Grem1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb development ( J:149484 )

• authors state that mice exhibit similar limb defects as those observed in Fmn1^tm2Made homozygotes

Allelic Composition	Alx4^lst/Alx4⁺ Grem1^ld-J/Grem1⁺
Genetic Background	involves: CBA/Ca * NHO

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^lst mutation (0 available); any Alx4 mutation (21 available)
Grem1^ld-J mutation (1 available); any Grem1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:35172 )

N	• have normal limbs

Allelic Composition	Alx4^lst/Alx4⁺ Grem1^ld/Grem1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4^lst mutation (0 available); any Alx4 mutation (21 available)
Grem1^ld mutation (0 available); any Grem1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:35172 )

N	• have normal limbs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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